胸腺基质淋巴细胞生成素基因多态性与子痫前期的相关性研究

发布时间：2018-05-21 17:49

本文选题：胸腺基质淋巴生成素 + 基因多态性　；参考：《中国实用妇科与产科杂志》2015年07期

【摘要】：目的探讨胸腺基质淋巴细胞生成素(TSLP)位点rs1898671、rs2289278,rs2289276及rs764916基因多态性与妊娠妇女子痫前期发生的相关性。方法收集2012年11月至2013年6月中国医科大学附属盛京医院分娩的孕妇384例。其中病例组181例,对照组203例,病例组又分为子痫前期轻度组(97例)和子痫前期重度组(84例)。选取TSLP4个位点(rs1898671,rs2289276,rs2289278 and rs764916),利用基质辅助激光解析电离飞行时间质谱(MALDITOF MS)技术分析该基因的4个位点。结果各临床资料在病例组与对照组比较中差异均有统计学意义(P0.05),子痫前期轻度组与对照组比较中除年龄外其他各临床资料比较,差异均有统计学意义(P0.05),子痫前期重度组与对照组以及子痫前期轻度组比较中各临床资料差异均有统计学意义(P0.05)。位点rs1898671等位基因频率在病例组与对照组中差异有统计学意义(P=0.043,OR=2.682,95%CI 1.020~7.054)。结论 TSLP位点rs1898671基因多态性与子痫前期的发病可能具有相关性。等位基因T为子痫前期的危险性等位基因。
[Abstract]:Objective to investigate the relationship between the polymorphism of thymic stromal lymphopoietin (TSLP) locus rs1898671rs2289278 and rs764916 gene and preeclampsia in pregnant women. Methods 384 pregnant women in Shengjing Hospital affiliated to China Medical University from November 2012 to June 2013 were collected. There were 181 cases in the case group and 203 cases in the control group. The case group was divided into mild preeclampsia group (97 cases) and severe preeclampsia group (84 cases). Four TSLP4 loci, rs2289276hrs2289278 and rs764916, were selected to analyze the four loci of the gene by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDITOF MS). Results there were significant differences in the clinical data between the case group and the control group (P 0.05). The clinical data of the mild preeclampsia group and the control group were compared with those of the control group except age. There were significant differences in the clinical data between the severe preeclampsia group and the control group and the mild preeclampsia group. There was significant difference in allele frequency of rs1898671 locus between the case group and the control group. Conclusion the polymorphism of rs1898671 gene at TSLP site may be associated with preeclampsia. Allele T is a risk allele for preeclampsia.
【作者单位】：中国医科大学附属盛京医院妇产科;国家计生委科学技术研究所遗传组;
【基金】：辽宁省科学技术计划(2011225017) 辽宁省自然基金(201404071)
【分类号】：R714.244

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