2748例住院孕妇妊娠期糖尿病发病率及危险因素的研究

发布时间：2018-05-23 21:52

  本文选题：妊娠期糖尿病 + 发病率　； 参考：《南京医科大学学报(自然科学版)》2015年05期

【摘要】：目的 :分析孕妇妊娠期糖尿病(gestational diabetes mellitus,GDM)发病情况及危险因素。方法 :收集2012年1月1日~2013年12月31日本院产科门诊随诊并住院分娩的孕妇资料2 748例,通过口服75 g葡萄糖耐量试验(OGTT)筛查GDM,评估发病率、相关危险因素。结果:12 748例孕妇中GDM 540例,非GDM 2 208例,GDM发病率19.65%;2GDM组年龄、孕前BMI、产前BMI、孕期体重增加值、新生儿体重较非GDM组均有升高(P0.05);3单因素分析显示年龄(≥30岁)(OR=1.868,P0.001)、自然流产史(OR=1.673,P0.001)、高血压病史(OR=2.509,P=0.017)、糖尿病家族史(OR=5.776,P0.001)、孕前BMI≥24(OR=2.981,P0.001)、孕期体重增长情况(OR=1.923,P0.001)均是GDM发生的相关危险因素。进一步行多因素Logistic回归显示年龄≥30岁(OR=1.406,P=0.006)、自然流产史(OR=1.462,P=0.003)、糖尿病家族史(OR=4.969,P0.001)、孕前BMI≥24(OR=1.475,P=0.035)、孕期体重增长幅度≥16.0 kg(OR=1.846,P0.001)与GDM发生有关;而妊娠期贫血孕妇GDM的发生率为无贫血孕妇的0.518倍(OR=0.518,P0.001);4无高危因素组GDM发病率11.95%,当高危因素≥4个,GDM发病率达65.00%(χ2=144.182,P0.001)。结论:孕前BMI≥24、年龄≥30岁、自然流产病史、DM家族史、孕期体重增加≥16 kg等因素为GDM发生的独立危险因素,妊娠期贫血可降低GDM发生。加强孕前、孕期高危因素筛查、干预,有利于减少GDM发生。
[Abstract]:Objective: to analyze the incidence and risk factors of gestational diabetes mellitusus (GDM) in pregnant women with gestational diabetes mellitus (GDM). Methods: from January 1, 2012 to December 31, 2013, 2 748 pregnant women who were followed up and delivered in hospital were collected. GDMs were screened by oral glucose tolerance test (OGTT), and the incidence and risk factors were evaluated. Results among 12 748 pregnant women, 540 cases were GDM, and 19.65 cases were non-GDM cases. The age, pre-pregnancy, prenatal GDM, weight gain during pregnancy were 19.65% and 19.65%, respectively. The univariate analysis showed that the age (鈮，

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