彩色多普勒超声评价反复种植失败患者子宫动脉血流特点研究

发布时间：2018-05-28 14:48

本文选题：彩色多普勒超声 + 子宫动脉搏动指数　；参考：《中国实用妇科与产科杂志》2015年02期

【摘要】：目的探讨反复种植失败(recurrent implantation failure,RIF)患者子宫动脉血流及其相关因素的特点。方法选取2012年3月至2013年8月于烟台毓璜顶医院生殖医学科因输卵管因素行体外受精-胚胎移植(in vitro fertilizationembryo transfer,IVF-ET)治疗的RIF患者(RIF组,n=40)为研究对象;同期IVF-ET治疗首次助孕成功的患者(首次IVF助孕成功组,n=40),首次IVF-ET助孕治疗失败患者(首次IVF助孕失败组,n=40)为对照组,进行回顾性分析。于注射人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日行经阴道彩色多普勒超声检查,测量子宫动脉搏动指数(uterine artery pulsatility index,UAPI)、子宫内膜厚度,并同时测定血雌二醇及孕酮值。比较三组间相关指标的差异。结果 RIF组患者UAPI 3.3±0.4,显著高于同期IVF-ET治疗首次助孕成功组2.3±0.5及失败组UAPI 2.4±0.4,差异有统计学意义(P0.05),而IVF-ET治疗首次助孕成功组与失败组相比,差异无统计学意义(P0.05)。3组间的子宫内膜厚度、雌二醇及孕酮值差异无统计学意义(P0.05)。结论 HCG日测定UAPI有助于评价子宫内膜容受性,预测种植率。
[Abstract]:Objective to investigate the characteristics of uterine artery blood flow and its related factors in patients with recurrent implantation failure. Methods from March 2012 to August 2013, patients with RIF treated with in vitro fertilization and embryo transfer in vitro fertilizationembryo transfer IVF-ETwere selected from the Department of Reproductive Medicine, Yuzhouding Hospital, Yantai, as the study objects. At the same time, the patients who were successfully treated with IVF-ET for the first time (the first successful IVF group) and the first failed IVF-ET group (the first failed IVF group) as the control group were retrospectively analyzed. Human chorionic gonadotropin (HCG) was injected with human chorionic gonadotropin (HCG). The uterine artery pulsatile index, endometrial thickness and serum estradiol and progesterone were measured by transvaginal color Doppler ultrasonography. To compare the differences of relative indexes among the three groups. Results the UAPI of RIF group was 3.3 卤0.4, which was significantly higher than that of IVF-ET group (2.3 卤0.5) and failed group (UAPI 2.4 卤0.4). The difference was statistically significant (P 0.05), while that of IVF-ET group was higher than that of failed group. There was no significant difference in endometrial thickness, estradiol and progesterone between the two groups (P 0.05). Conclusion HCG day measurement of UAPI is helpful to evaluate endometrial receptivity and predict implantation rate.
【作者单位】：青岛大学医学院附属烟台毓璜顶医院生殖医学科;青岛大学医学院附属烟台毓璜顶医院超声室;
【基金】：国家自然科学基金面上项目(81370013) 烟台市科技发展技术项目(2013WS207)
【分类号】：R445.1;R714.8

【共引文献】