RET基因在宫颈鳞癌中的表达及与预后的关系

发布时间：2018-05-29 17:43

本文选题：子宫颈鳞状细胞癌 + 转染期间重排基因RET　；参考：《实用医学杂志》2017年06期

【摘要】：目的:探讨宫颈鳞癌组织中RET蛋白的表达与临床病理组织学特征及患者预后的联系。方法:采用免疫组化法在正常宫颈组织、宫颈上皮内瘤变组织及宫颈鳞癌组织的蜡块切片中检测RET蛋白在组织中的定位分布和表达。结合临床病理资料、随访数据和RET蛋白表达进行预后分析。结果:RET蛋白在宫颈鳞癌组织中表达率较其他组织更高。宫颈鳞癌组织中RET蛋白高表达与FIGO分期及肿瘤分化程度有关(P0.05),与患者年龄及淋巴结转移无关(P0.05)。Kaplan-Meier法生存分析和Log-rank检验表明:宫颈鳞癌组织中RET蛋白表达阳性患者比阴性患者的无瘤生存期短,差异具有显著性(P0.05)。COX比例风险回归模型预后分析发现,RET蛋白的表达和淋巴结转移是宫颈鳞癌患者的独立预后因素。结论:RET蛋白在宫颈鳞癌的发生发展、临床分期中起了一定的促进作用。
[Abstract]:Objective: to investigate the relationship between the expression of RET protein and the clinicopathological features and prognosis of cervical squamous cell carcinoma (SCC). Methods: immunohistochemical method was used to detect the distribution and expression of RET protein in the paraffin sections of normal cervical tissues, cervical intraepithelial neoplasia tissues and cervical squamous cell carcinoma tissues. Combined with clinicopathological data, follow-up data and RET protein expression for prognostic analysis. Results the expression rate of the protein in squamous cell carcinoma of cervix was higher than that in other tissues. The high expression of RET protein in cervical squamous cell carcinoma was related to FIGO stage and tumor differentiation, but not to patient's age and lymph node metastasis. The survival analysis and Log-rank test showed that the expression of RET protein in cervical squamous cell carcinoma was higher than that in patient with P0.05. Kaplan-Meier method. The tumor-free survival of negative patients was short. The prognostic analysis showed that the expression of RET protein and lymph node metastasis were independent prognostic factors in patients with squamous cell carcinoma of the cervix. ConclusionThe protein of Ret plays an important role in the development of squamous cell carcinoma of the cervix and plays an important role in the clinical stage of cervix squamous cell carcinoma.
【作者单位】：中南大学湘雅医学院附属海口医院;
【基金】：海南省自然科学基金资助项目(编号:20158288)
【分类号】：R737.33

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