妊高征患者血浆N端脑钠肽前体水平与左心室舒张功能及血压变化的关系

发布时间：2018-05-30 11:21

本文选题：妊娠高血压综合征 + N端脑钠肽前体　；参考：《山东医药》2017年01期

【摘要】：目的探讨妊高征患者血浆N端脑钠肽前体(NT-proBNP)水平与左心室舒张功能及血压变化的相关性,评价其对妊高征患者发生心力衰竭的预测价值。方法选择年龄匹配的正常妊娠孕妇和妊高征孕妇各40例,应用彩色多普勒技术检测孕妇二尖瓣血流舒张早期充盈峰(E)、E峰速度时间积分(EVTI)、舒张晚期充盈峰(A)、A峰速度时间积分(AVTI)以及E/A比值,采用电化学发光双抗体夹心法测定血浆NT-proBNP水平,同时进行24 h动态血压监测;比较正常妊娠孕妇和妊高征孕妇血浆NT-proBNP水平并分析其与左心室舒张功能和血压的关系。结果妊高征患者血浆NT-proBNP水平高于正常妊娠孕妇(P0.05)。NT-proBNP水平与E、A、EVTI、AVTI呈正相关(r分别为0.653、0.726、0.811、0.763,P均0.05)。妊高征患者NT-proBNP水平与24 h舒张压呈正相关(r=0.835,P0.01)。结论妊高征患者NT-proBNP水平与血压水平和左心室舒张功能变化相关,血浆NT-proBNP水平可敏感反映妊高征患者发生心力衰竭的可能性。
[Abstract]:Objective to investigate the relationship between plasma N-terminal brain natriuretic peptide precursor (NT-proBNPP) and left ventricular diastolic function and blood pressure in patients with pregnancy induced hypertension (PIH), and to evaluate the predictive value of NT-proBNPs in predicting heart failure in patients with PIH. Methods 40 normal pregnant women and 40 pregnant women with PIH were selected. The early diastolic peak of mitral valve in pregnant women (EVTI) and the ratio of E / A and E / A were measured by color Doppler technique. The plasma NT-proBNP levels were measured by electrochemiluminescence double antibody sandwich method. At the same time, 24 h ambulatory blood pressure monitoring was performed to compare plasma NT-proBNP levels between normal pregnant women and pregnant women with pregnancy induced hypertension (PIH) and to analyze its relationship with left ventricular diastolic function and blood pressure. Results the plasma NT-proBNP level in PIH patients was higher than that in normal pregnant women. There was a positive correlation between NT-proBNP level and 24 h diastolic blood pressure in patients with PIH. Conclusion NT-proBNP level is correlated with blood pressure and left ventricular diastolic function in patients with PIH. Plasma NT-proBNP level can reflect the possibility of heart failure in PIH patients.
【作者单位】：中山市东凤人民医院;中山市黄圃人民医院;
【分类号】：R714.246

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