子宫内膜样腺癌术后组织中claudin3、7和E-cadherin的表达及关系

发布时间：2018-05-30 20:21

本文选题：子宫内膜样腺癌 + claudin　；参考：《中国老年学杂志》2015年20期

【摘要】：目的检测子宫内膜样腺癌术后组织中claudin3蛋白(claudin3)、claudin7蛋白(claudin7)和上皮型钙黏素(E-cadherin)的表达,关注其相关性。方法 63例子宫内膜样腺癌患者临床资料及术后标本作为观察组,46例子宫内膜复杂性增生患者的子宫内膜组织作为对照组1,46例子宫内膜单纯性增生患者的子宫内膜作为对照组2。应用免疫组化SP法检测3组claudin3、7和E-cadherin的表达。结果 3组中claudin3、7和Ecadherin表达阳性率差别均有统计学意义。观察组中claudin3、7和E-cadherin表达的阳性率与肿瘤最大径、肌层浸润深度及脉管内瘤栓相关。claudin3、7与肿瘤的分化程度相关。相关性分析显示观察组中claudin3和E-cadherin、claudin7和E-cadherin均具有正相关性。结论子宫内膜样腺癌术后组织中claudin3、7和E-cadherin低表达对促进肿瘤性病变的形成及进展有一定意义,三者可能具有协同作用。
[Abstract]:Objective to investigate the expression of claudin3 protein claudin7 and E-cadherin in endometrial adenocarcinoma after operation. Methods the clinical data of 63 patients with endometrial adenocarcinoma and the postoperative specimens were used as the control group (n = 46). The endometrium of 46 patients with complicated hyperplasia of endometrium served as the control group (n = 46) and the endometrium of the patients with simple hyperplasia of endometrium (n = 46) was taken as the control group (n = 2). Immunohistochemical SP method was used to detect the expression of claudin 3 P 7 and E-cadherin in 3 groups. Results the positive rates of claudin 3 and Ecadherin in the three groups were significantly different. The positive rate of claudin3m7 and E-cadherin expression was correlated with the maximum diameter of the tumor, the depth of myometrial invasion and the tumor embolus in the vessel. Correlation analysis showed that there was a positive correlation between claudin3 and E-cadherin 7 and E-cadherin in the observation group. Conclusion the low expression of claudin 3n 7 and E-cadherin in endometrioid adenocarcinoma after operation may play a synergistic role in promoting the formation and progression of neoplastic lesions.
【作者单位】：辽宁医学院附属第一医院妇产科;
【分类号】：R737.33

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