妊娠期糖尿病孕妇血浆凝集素和内毒素水平与体质指数的相关性
发布时间:2018-05-31 16:07
本文选题:妊娠期糖尿病 + 甘露糖结合凝集素 ; 参考:《实用医学杂志》2015年20期
【摘要】:目的:探讨妊娠期糖尿病(GDM)孕妇血浆甘露糖结合凝集素(MBL)及内毒素(LPS)水平变化及其与体质指数(BMI)的关系。方法:纳入新诊断的GDM组孕妇及正常组孕妇各45例,测定血浆MBL、LPS浓度;每组按BMI(25 kg/m2)为界分为肥胖亚组(BMI≥25 kg/m2)和非肥胖亚组(BMI25 kg/m2),分析GDM组孕妇血浆MBL、LPS水平变化及其与BMI的相关性。结果 :GDM组MBL浓度低于正常组,而LPS浓度明显高于正常组,差异具有统计学意义(P0.05);Pearson相关性分析显示GDM孕妇血浆BMI与MBL呈负相关(r=-0.28,P0.05),BMI与LPS呈明显正相关(r=0.62,P0.05);LPS与MBL呈负相关(r=-0.43,P0.05)。正常组MBL、LPS与BMI之间的这种相关性不存在。结论 :MBL和LPS可能是超重孕妇GDM发病的两个重要危险因素,对临床GDM防治可能具有重要意义。
[Abstract]:Objective: to investigate the changes of plasma mannose binding lectin (MBL) and endotoxin (LPS) levels in pregnant women with gestational diabetes mellitus (GDM) and the relationship between plasma mannose binding lectin (MBL) and body mass index (BMI). Methods: the plasma concentration of GDM was measured in 45 pregnant women in the newly diagnosed group and 45 pregnant women in the normal group. Each group was divided into obese subgroup (BMI 鈮,
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