孕妇血清叶酸、同型半胱氨酸的水平与胎儿先天性心脏病的相关性

发布时间：2018-05-31 23:00

  本文选题：先天性心脏病 + 叶酸　； 参考：《山东医药》2015年37期

【摘要】：目的观察孕妇血清叶酸(FA)和同型半胱氨酸(Hcy)水平变化并探讨其与胎儿先天性心脏病(CHD)的关系。方法选择有胎儿CHD的孕妇46例为病例组,无胎儿CHD的孕妇43例为对照组。采用竞争法测定血清FA水平,酶法测定血清Hcy水平,比较两组血清FA和Hcy水平的差异。采用单因素及多因素Logistic回归分析各指标间的相关性。结果病例组的FA水平低于对照组(t=2.426,P0.017);病例组Hcy水平高于对照组,但差异无统计学意义(P0.05)。孕妇体质量高、血清FA水平低是胎儿发生CHD的危险因素。血清FA≥41.6 nmol/L的孕妇与32.5 nmol/L的孕妇相比,胎儿CHD发生率降低36倍,是胎儿患CHD的保护因素;Hcy的OR=1.036,95%CI:0.807~1.329,但并未增加胎儿CHD发生的危险性(P0.05)。结论孕妇血清高水平FA是胎儿CHD的保护因素,血清FA水平对胎儿CHD的发生有预测价值。
[Abstract]:Objective to investigate the changes of serum folate (FA) and homocysteine (Hcy) levels in pregnant women and their relationship with fetal congenital heart disease (CHD). Methods 46 pregnant women with fetal CHD were selected as case group and 43 pregnant women without fetal CHD as control group. The levels of serum FA and Hcy were measured by competition law and enzymatic method respectively. The differences of FA and Hcy levels between the two groups were compared. Univariate and multivariate Logistic regression analysis was used to analyze the correlation among the indexes. Results the FA level in the case group was lower than that in the control group (2.426p 0.017), and the Hcy level in the case group was higher than that in the control group, but the difference was not statistically significant (P 0.05). High body mass and low serum FA level are the risk factors of fetal CHD. The incidence of fetal CHD in pregnant women with FA 鈮，

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