妊娠期糖尿病孕妇分娩前后脂肪细胞型脂肪酸结合蛋白水平的变化

发布时间：2018-06-02 01:41

本文选题：脂肪细胞脂肪酸结合蛋白 + 妊娠期糖尿病　；参考：《广东医学》2017年02期

【摘要】：目的探讨妊娠期糖尿病(GDM)孕妇分娩前后血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平的变化。方法选择常规产前及产后检查的GDM孕妇共70例,其中妊娠中期(孕24~28周)妇女35例为GDM组,产后6周血糖恢复正常妇女35例为对照组。测定体质指数(BMI)、血压(BP)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、服糖后1、2 h血糖(1h PG、2h PG)、肌酐、血尿酸、血清A-FABP及空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR)。结果GDM组与对照组相比,BMI、HOMA-IR、1h PG、2h PG、FINS、TG、TC、LDL-C显著增高(P0.05);A-FABP在GDM组的水平比对照组升高,差异有统计学意义(P0.05),且与BMI、收缩压(SBP)、FPG、2h PG、FINS、HOMAIR呈正相关(P0.01)。结论血清A-FABP可能参与了GDM的发生、发展,影响分娩前后血糖变化。
[Abstract]:Objective to investigate the changes of serum adipocytic fatty acid binding protein (AFABPP) levels in pregnant women with GDM before and after delivery. Methods A total of 70 pregnant women with GDM were enrolled in the routine prenatal and postnatal examination. 35 cases of women in the second trimester of pregnancy (24 ~ 28 weeks of pregnancy) were selected as GDM group, and 35 cases of women with normal blood glucose at 6 weeks postpartum as control group. Body mass index (BMI), blood pressure (BP), triglyceride (TG), cholesterol triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), serum creatinine, serum uric acid, serum A-FABP and fasting insulin (fins) were measured. The insulin resistance index was calculated. Results compared with the control group, the level of LDL-C in the GDM group was significantly higher than that in the control group. The level of LDL-C in the GDM group was significantly higher than that in the control group (P 0.05). Conclusion Serum A-FABP may be involved in the occurrence and development of GDM and affect the changes of blood glucose before and after delivery.
【作者单位】：广东省妇幼保健院内科;
【分类号】：R714.256

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