米非司酮联合米索前列醇用于药物流产的临床观察

发布时间：2018-06-03 07:20

本文选题：米非司酮 + 米索前列醇　；参考：《中国药房》2015年09期

【摘要】：目的:观察米非司酮联合米索前列醇用于药物流产的临床疗效和安全性。方法:将580例以药物流产终止妊娠的妊娠期妇女随机均分为观察组和对照组,观察组有11例未完成研究,共纳入279例;对照组有9例未完成研究,共纳入281例。观察组给予米非司酮胶囊首次剂量20 mg,后每12 h 1次,每次10 mg,总量130 mg;并于用药第3天早晨加用米索前列醇片600μg,第4~6天早晨分别服用200μg,总量1 200μg。对照组给予米非司酮胶囊首次剂量20 mg,后每12 h 1次,每次10 mg,总量50 mg;并于用药第3天早晨服用米索前列醇片600μg。观察两组患者的临床疗效、出血情况(出血持续时间、出血量)及不良反应发生情况。结果:观察组妊娠期妇女总有效率、出血持续时间以及出血持续天数≤10 d、出血持续天数≤15 d、出血量≤月经量的例数均显著优于对照组,两组比较差异均有统计学意义(P0.01);但不良反应发生率比较,差异无统计学意义(P0.05)。结论:通过延长米非司酮与米索前列醇的用药时间可显著提高完全流产率,减少出血时间,且安全性较好。
[Abstract]:Objective: To observe the clinical efficacy and safety of mifepristone combined with misoprostol in the use of misoprostol. Methods: 580 cases of pregnant women with termination of pregnancy were randomly divided into observation group and control group. In the observation group, 11 cases were not completed, and 279 cases were included in the control group; 9 cases in the control group were not completed, and 281 cases were included in the observation group. The first dose of Mifepristone Capsules was 20 mg, then 1 times per 12 h, 10 mg each time, and the total amount was 130 mg, and the dosage of mica proprostol was 600 mu g on the morning of the third morning, and 200 mu g in the morning of the next morning. The total amount of 1200 u g. control group was 20 mg at the first dose of Mifepristone Capsules, then every 12 h 1, every time 10 mg, total 50 mg. In the morning, Misoprostol Tablets 600 mu g. was used to observe the clinical efficacy of two groups of patients, bleeding (bleeding duration, bleeding volume) and adverse reactions. Results: the total effective rate of women in the observation group, the duration of bleeding and the duration of bleeding were less than 10 d, the duration of bleeding was less than 15 d, and the number of bleeding amount equal to the amount of menstruation was significant. Compared with the control group, there were significant differences in the two groups (P0.01), but there was no significant difference in the incidence of adverse reactions (P0.05). Conclusion: prolonging the time of mifepristone and misoprostol can significantly increase the rate of complete abortion, reduce the time of bleeding, and have better safety.
【作者单位】：广州市妇女儿童医疗中心;广州市南沙区人口和计划生育服务站;
【基金】：广东省人口计生委科研项目(No.20133099)
【分类号】：R169.42

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