基于先验知识的宫颈癌调强计划自动优化的可行性研究

发布时间：2018-06-03 07:48

  本文选题：经验引导调强计划 + 常规调强计划　； 参考：《中华肿瘤防治杂志》2015年23期

【摘要】：目的通过比较宫颈癌经验引导调强(knowledge-based intensity-modulated radiotherapy,K-IMRT)与常规调强(conventional intensity-modulated radiotherapy,C-IMRT)在计划靶区(planning target volume,PTV)和危及器官(organ at risk,OAR)的剂量学差异,探讨基于先验知识的宫颈癌调强计划自动优化的可行性。方法选取山东省肿瘤医院2014-05-01-2014-09-01宫颈癌术后患者10例,进行CT模拟定位、靶区和危及器官的勾画,用Eclipse 13.0治疗计划系统基于同一CT图像进行K-IMRT和C-IMRT调强计划设计。在95%体积的PTV达到处方剂量的条件下,比较两种调强计划的剂量体积直方图(dose volume histogram,DVH),分析靶区均匀性指数(homogeneity index,HI)、适形度指数(conformity index,CI)、OAR受照剂量和计划时间。结果 K-IMRT计划与C-IMRT计划在靶区受照剂量、HI和CI差异均无统计学意义,P0.05。膀胱V30、左股骨头V40、右股骨头V20、V30和D50K-IMRT计划明显优于C-IMRT计划,差异有统计学意义,P0.05。膀胱V20、V30和D50,直肠V20、V30和V50及左右股骨头受照剂量均值都低于C-IMRT计划。计划时间K-IMRT明显缩短。结论宫颈癌术后基于先验知识的调强计划自动优化结果可以达到与C-IMRT计划相似的靶区剂量分布,能够降低危及器官的受照受量,在计划优化应用中是可行的。
[Abstract]:Objective to compare the dosimetric differences between Knowledge-based intensity-modulated radiotherapyn K-IMRT (Knowledge-based intensity-modulated radiotherapyn) and C-IMRT (conventional intensity modulated intensity-modulated radiotherapyn) in the planning target area of cervical cancer, and to explore the feasibility of automatic optimization of cervical cancer intensity modulation plan based on prior knowledge. Methods Ten patients with cervical cancer were selected from 2014-05-01-2014-09-01 cervical cancer surgery in Shandong Cancer Hospital. Ct simulation location, target area and dangerous organs were delineated. The K-IMRT and C-IMRT intensity modulation plans were designed with Eclipse 13.0 treatment planning system based on the same CT images. Under the condition that 95% volume PTV reached the prescribed dose, the dose volume histogram and dose volume histogramme of the two intensity modulated plans were compared, and the homogeneity index and conformity index were analyzed. Results there was no significant difference in HI and CI between K-IMRT program and C-IMRT plan in target area (P 0.05). Bladder V30, left femoral head V40, right femoral head V20 V30 and D50K-IMRT plan were significantly superior to C-IMRT plan (P 0.05). The mean values of V30 and D50 in bladder, V30 and V50 in rectum, and in the left and right femoral head were lower than those in C-IMRT plan. The planning time K-IMRT was shortened obviously. Conclusion the automatic optimization results of intensity modulation plan based on prior knowledge after cervical cancer operation can reach the dose distribution of target area similar to that of C-IMRT plan, and can reduce the exposure to radiation of endangered organs, which is feasible in the application of planning optimization.
【作者单位】： 济南大学·山东省医学科学院医学与生命科学学院;山东省肿瘤医院物理室;莱芜市人民医院放疗科;
【基金】：山东省自然科学基金(ZR2013HL044)
【分类号】：R737.33
，

本文编号：1972038