糖代谢中关键酶果糖双磷酸酶-1与卵巢癌化疗敏感性关系的研究

发布时间：2018-06-03 23:04

本文选题：果糖双磷酸酶- + 卵巢癌　；参考：《中国癌症杂志》2017年05期

【摘要】：背景与目的:上皮性卵巢癌是女性生殖系统恶性肿瘤中死亡率最高的肿瘤。化疗期间耐药的产生是卵巢癌死亡率高的主要原因。果糖双磷酸酶-1(fructose-1,6-bisphosphatase,FBP1)是糖代谢过程中的关键酶。FBP1用于催化1,6-二磷酸果糖水解为6-磷酸果糖和磷酸盐,从而抑制细胞的糖酵解。该研究旨在探讨FBP1与卵巢癌化疗敏感性关系。方法:采用免疫组织化学方法检测209例卵巢癌患者标本中FBP1蛋白的表达水平及其与卵巢癌患者化疗敏感性的关系。结果:在209例卵巢癌组织中,FBP1的阳性表达率为49.3%(103/209),FBP1表达阳性组患者生存期长于阴性组,二者之间差异有统计学意义(42.6个月vs 62.1个月,P=0.003),并且FBP1表达与化疗敏感性相关(P=0.007)。结论:糖代谢中关键酶基因FBP1的表达可能与卵巢癌对化疗的敏感性有关,可作为化疗敏感性及预后判断的重要指标。
[Abstract]:Background & objective: epithelial ovarian cancer is one of the most fatal tumors in female reproductive system. Drug resistance during chemotherapy is the main cause of high mortality of ovarian cancer. Fructose-1) is a key enzyme in the process of glucose metabolism. FBP1 is used to catalyze the hydrolysis of fructose-6-bisphosphatase1 to fructose 6-phosphate and phosphate in order to inhibit the glycolysis of cells. The aim of this study was to investigate the relationship between FBP1 and chemosensitivity of ovarian cancer. Methods: immunohistochemical method was used to detect the expression of FBP1 protein and its relationship with chemosensitivity in 209 patients with ovarian cancer. Results: the positive expression rate of FBP1 in 209 cases of ovarian cancer was 49.3%, and the survival time of patients with positive expression of FBP1 was 103 / 209. The difference between the two groups was statistically significant (42.6 months vs 62.1 months, P < 0.001), and the expression of FBP1 was related to chemosensitivity (P 0.007). Conclusion: the expression of key enzyme gene FBP1 in glucose metabolism may be related to the sensitivity of ovarian cancer to chemotherapy and can be used as an important index to judge the chemosensitivity and prognosis of ovarian cancer.
【作者单位】：复旦大学附属肿瘤医院妇瘤科复旦大学上海医学院肿瘤学系;复旦大学附属肿瘤医院肿瘤研究所复旦大学上海医学院肿瘤学系;
【基金】：国家自然科学基金青年科学基金项目(NSFC1212)
【分类号】：R737.31

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