成都地区足月新生儿胎盘铅镉元素的分布特点

发布时间：2018-06-04 06:24

本文选题：胎盘 + 铅　；参考：《重庆医学》2017年31期

【摘要】：目的调查足月新生儿胎盘不同取样位置样品的铅镉含量,探讨胎盘样品在宫内重金属暴露评价中的作用。方法收集四川大学华西第二医院2016年5-6月30个健康足月新生儿胎盘,以脐带横截面脐静脉为12点钟方向将胎盘子面分为左右两个部分,分别在左部1/4半径处(A点)和右部分3/4半径处(B点)采集绒毛小叶组织样品;应用石墨炉原子吸收光谱法检测样品铅镉含量,对A、B位置间元素含量进行相关分析和配对t检验。结果胎盘A点干重样品的平均铅、镉含量分别为91.8、66.7μg/kg,B点干重样品相应的平均含量为88.9、64.8μg/kg。两个部位的铅、镉含量均呈正相关,相关系数分别为0.98和0.97,且不同部位组织间的含量差异无统计学意义(P0.05)。结论胎盘子面中心部分(1/4~3/4半径区域)绒毛小叶组织中铅镉含量基本一致,是评价宫内重金属暴露的可靠指标。
[Abstract]:Objective to investigate the content of lead and cadmium in placenta samples from full-term neonates and to explore the role of placental samples in the evaluation of intrauterine heavy metal exposure. Methods the placenta of 30 healthy full-term newborns from May to June 2016 in West China second Hospital of Sichuan University was collected. The placenta was divided into two parts with umbilical cord cross section at 12 o'clock. The samples of villi were collected at point A of 1 / 4 radius on the left and point B at the radius of 3 / 4 on the right. The contents of lead and cadmium in the samples were detected by graphite furnace atomic absorption spectrometry. Results the average contents of lead and cadmium in dry weight samples at point A of placenta were 91.86.7渭 g / kg / kg B and 64.8 渭 g / kg / kg 路kg ~ (-1) 路kg ~ (-1) respectively. The contents of lead and cadmium in the two parts were positively correlated, the correlation coefficients were 0.98 and 0.97, respectively, and there was no significant difference in the content of lead and cadmium between the two parts. Conclusion the contents of lead and cadmium in the villi of placental placenta with a 1 / 4 / 3 / 4 radius region are basically the same, which is a reliable index to evaluate the exposure to heavy metals in the uterus.
【作者单位】：四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室;四川大学华西第二医院妇产科;四川大学华西公共卫生学院卫生检验系;四川大学华西第二医院中国出生缺陷监测中心;
【基金】：国家自然科学基金资助项目(81673257) 四川省科技厅项目(2013SZ0179)
【分类号】：R714

【相似文献】