子宫癌肉瘤106例临床分析

发布时间：2018-06-04 23:54

本文选题：子宫肿瘤 + 癌肉瘤　；参考：《中国实用妇科与产科杂志》2015年10期

【摘要】：目的探讨子宫癌肉瘤的临床特点及预后影响因素。方法收集2000年1月至2012年1月广东省子宫内膜癌防治项目经手术病理确诊并有随访资料的106例子宫癌肉瘤病例。对其进行回顾性分析,探讨临床特点、组织学类型、手术病理分期、手术范围、术后辅助治疗的特点及其与预后的关系。结果子宫癌肉瘤的发病年龄为(55.8±0.9)岁。最常见首发症状为异常子宫出血,临床上多采用手术联合放化疗的治疗方案。总体生存时间92.4个月,中位生存时间78.8个月,3年、5年总体生存率分别为69.2%、55.3%。单因素分析显示:合并糖尿病、附件转移、肿瘤大小、手术-病理分期、术后辅助治疗与预后有关(P0.05)。多因素分析显示:肿瘤大小、手术-病理分期是子宫癌肉瘤的独立预后因素(P0.05)。结论子宫癌肉瘤是侵袭性肿瘤,早期诊断、综合治疗对提高子宫癌肉瘤的生存率有重要意义。
[Abstract]:Objective to investigate the clinical features and prognostic factors of uterine carcinosarcoma. Methods 106 cases of uterine carcinosarcoma were collected from January 2000 to January 2012 in Guangdong Province, which were confirmed by operation and pathology and followed up. The clinical features, histological types, surgical pathological stages, surgical scope, the characteristics of postoperative adjuvant therapy and their relationship with prognosis were analyzed retrospectively. Results the onset age of uterine carcinosarcoma was 55.8 卤0.9 years old. The most common initial symptom is abnormal uterine hemorrhage. The overall survival time was 92.4 months, the median survival time was 78.8 months, the overall survival rate of 3 years and 5 years was 69.2% and 55.3% respectively. Univariate analysis showed that diabetes mellitus, adnexal metastasis, tumor size, operation-pathological stage, postoperative adjuvant therapy were associated with prognosis (P 0.05). Multivariate analysis showed that tumor size, surgical and pathological stages were independent prognostic factors of uterine carcinosarcoma (P 0.05). Conclusion uterine carcinosarcoma is an invasive tumor. Early diagnosis and comprehensive treatment are important to improve the survival rate of uterine carcinosarcoma.
【作者单位】：中山大学附属第三医院妇科;
【基金】：广东省自然科学基金(S2012010008) 国家自然科学基金(30772332) 广东省妇幼安康工程—子宫内膜癌防治项目
【分类号】：R737.33

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