妊娠晚期B族链球菌阳性孕妇血清IL-6、降钙素原水平变化及意义

发布时间：2018-06-04 23:55

本文选题：妊娠晚期 + B族链球菌感染　；参考：《山东医药》2015年48期

【摘要】：目的探讨血清IL-6、降钙素原(PCT)水平在妊娠晚期B族链球菌(GBS)阳性孕妇感染状态判断中的价值。方法选择妊娠晚期GBS阳性孕妇90例(GBS组),其中GBS带菌23例、GBS亚临床感染(以下称GBS亚感染)60例、绒毛膜羊膜炎(以下称羊膜炎)7例;选择妊娠晚期正常孕妇30例(对照组)。两组分娩后采用电化学发光法检测血清IL-6、PCT水平,分析GBS组不同GBS感染状态者血清IL-6、PCT水平变化。结果 GBS组及对照组血清IL-6水平分别为(16.96±5.23)、(2.86±0.54)pmol/m L,PCT水平分别为(0.08±0.03)、(0.04±0.02)ng/m L,P均0.01。GBS组羊膜炎者血清IL-6、PCT水平均高于GBS亚感染及GBS带菌者,GBS亚感染者高于GBS带菌者(P均0.01)。结论妊娠晚期GBS阳性孕妇血清IL-6、PCT水平升高,可作为判断妊娠晚期GBS感染状态的指标。
[Abstract]:Objective to investigate the value of serum IL-6 and procalcitonin (PCT) levels in the diagnosis of infection status of pregnant women with Group B Streptococcus B (GBS) positive in the third trimester of pregnancy. Methods A total of 90 cases of GBS positive pregnant women in late pregnancy were selected. Among them, 23 cases were infected with GBS subclinical infection (60 cases were referred to as GBS subinfection), 7 cases were chorioamnionitis (hereinafter referred to as amnionitis), 30 cases were normal pregnant women (control group). After delivery, the serum levels of IL-6 and PCT were detected by electrochemiluminescence method, and the changes of serum IL-6 and PCT levels in patients with different GBS infection status were analyzed. Results Serum IL-6 levels in patients with amnionitis were higher than those in patients with GBS subinfection and those with GBS carriers (P < 0.01). The serum levels of IL-6 in patients with amnionitis were higher than those in patients with GBS subinfection and those with GBS subinfection (2.86 卤0.03) and (0.04 卤0.03) 0.02)ng/m / L (P < 0.05) respectively. The levels of IL-6 / PCT in patients with amnionitis were significantly higher than those in patients with GBS subinfection and those with GBS carriers (P < 0.01). Conclusion the level of serum IL-6 + PCT in GBS positive pregnant women is increased in late pregnancy, which can be used as an index to judge the status of GBS infection in the third trimester of pregnancy.
【作者单位】：南方医科大学附属小榄医院;
【基金】：中山市第一批科技计划项目(2014A1FC025)
【分类号】：R714.251

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