妊娠糖尿病患者骨代谢标志物水平分析

发布时间：2018-06-05 23:10

本文选题：妊娠糖尿病 + 骨代谢标志物　；参考：《中国骨质疏松杂志》2015年12期

【摘要】：目的探讨妊娠糖尿病患者血清N端-骨钙素、总I型胶原氨基端延长肽、β-胶原特殊序列、25-羟基维生素D和甲状旁腺激素水平的变化。方法采用病例对照研究,选取妊娠糖尿病患者(GDM组)与同孕周糖耐量正常的孕妇(NGT组)各50例,测定N端-骨钙素、总I型胶原氨基端延长肽、β-胶原特殊序列、25-羟基维生素D和甲状旁腺激素水平,比较两组人群临床资料和骨代谢标志物水平的差异并进行统计学分析。结果 GDM组孕妇的血清总I型胶原氨基端延长肽为(47.87±34.84)μg/L,明显高于NGT组的(35.48±10.61)μg/L(P=0.018),血清β-胶原特殊序列为(0.226±0.095)μg/L,明显高于NGT组的(0.193±0.054)μg/L(P=0.038),血清N端-骨钙素为(9.82±4.74)μg/L,明显高于NGT组的(7.74±1.92)μg/L(P=0.005)。25-羟基维生素D和甲状旁腺激素水平两组间差异无统计学意义。结论 GDM组患者的骨代谢状态主要表现为骨合成代谢和骨吸收代谢均有升高,同时骨转换率也明显升高,尚未发现维生素D和甲状旁腺激素水平与糖耐量正常的孕妇之间有明显差异。
[Abstract]:Objective to investigate the changes of serum N-terminal osteocalcin, total type I collagen amino terminal prolongation peptide, 尾 -collagen specific sequence 25 hydroxyvitamin D and parathyroid hormone in patients with gestational diabetes mellitus. Methods A case-control study was conducted in 50 patients with gestational diabetes mellitus (GDM) and 50 pregnant women with normal gestational glucose tolerance (NGT). The amino terminal lengthening peptide of total type I collagen, 尾 -collagen special sequence 25-hydroxyvitamin D and parathyroid hormone levels were compared between the two groups, and the differences of clinical data and bone metabolic markers between the two groups were analyzed statistically. Results the total amino terminal prolongation peptide of type I collagen in GDM group was 47.87 卤34.84 渭 g / L, which was significantly higher than that in NGT group (35.48 卤10.61) 渭 g / L, and the specific sequence of serum 尾 -collagen was 0.226 卤0.095 渭 g / L, which was significantly higher than that in NGT group (0.193 卤0.054) 渭 g / L, and serum N-terminal osteocalcin was 9.82 卤4.74 渭 g / L, which was significantly higher than that in NGT group (7.74 卤1.92) 渭 g / L P = 0.0055.25 There was no significant difference in vitamin D and parathyroid hormone levels between the two groups. Conclusion the bone metabolism of GDM patients is mainly characterized by the increase of bone biosynthesis and bone resorption, as well as the increase of bone turnover rate. Significant differences between vitamin D and parathyroid hormone levels and glucose tolerance were not found.
【作者单位】：安徽医科大学解放军306医院临床学院;解放军306医院检验科;
【分类号】：R714.256

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