血清肿瘤标志物联合检测对卵巢癌的诊断价值

发布时间：2018-06-06 00:48

本文选题：卵巢肿瘤 + 诊断　；参考：《临床合理用药杂志》2016年33期

【摘要】：目的分析血清中人附睾蛋白4(HE4)、碳水化合物抗原(CA125、CA199)、癌胚抗原(CEA)等血清肿瘤标志物联合检测对卵巢癌的诊断价值。方法选取安阳市肿瘤医院2013年11月—2015年10月收治的卵巢癌患者34例为观察组,选取本院同期卵巢良性肿瘤患者36例为对照组甲,选取本院同期进行健康体检的志愿者35例为对照组乙。比较3组受检者HE4、CA125、CA199、CEA水平及不同检测项目阳性率。结果观察组血清中HE4、CA125、CA199、CEA水平高于对照组甲和对照组乙,差异有统计学意义(P0.05);对照组甲HE4、CA125、CA199、CEA水平高于对照组乙,差异有统计学意义(P0.05)。检测HE4+CA125、HE4+CA125+CEA、HE4+CA125+CA199阳性率高于单一指标检测,差异有统计学意义(P0.05);检测HE4+CA125+CA199+CEA阳性率高于其他组合检测,差异有统计学意义(P0.05)。结论血清肿瘤标志物HE4、CA125、CA199及CEA联合检测能有效提高卵巢癌的检出率。
[Abstract]:Objective to analyze the diagnostic value of serum tumor markers such as human epididymal protein (Hepididymis 4), carbohydrate antigen (CA125) and carcinoembryonic antigen (CEA) in the diagnosis of ovarian cancer. Methods 34 patients with ovarian cancer treated in Anyang Cancer Hospital from November 2013 to October 2015 were selected as observation group and 36 patients with benign ovarian tumor as control group. 35 healthy volunteers were selected as control group B. CEA level and positive rate of different test items were compared among three groups. Results the level of CEA in serum of the observation group was higher than that of the control group (P 0.05) and the control group (P 0.05), and that of the control group was higher than that of the control group (P 0.05). The positive rate of HE4 CA125H4 CA125 CEAA-HE4 CA125 CA199 was higher than that of single index, the difference was statistically significant (P 0.05), and the positive rate of HE4 CA125 CA199 CEA was higher than that of other combinations (P 0.05). Conclusion the combined detection of serum tumor marker HE4, CA125, CA199 and CEA can effectively improve the detection rate of ovarian cancer.
【作者单位】：河南省安阳市肿瘤医院检验科;
【分类号】：R737.31;R730.43

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