子宫内膜样腺癌组织Twist和HIF-1α及E-cadherin表达的临床意义

发布时间：2018-06-06 15:30

本文选题：子宫内膜样腺癌/病理学 + Twist　；参考：《中华肿瘤防治杂志》2015年11期

【摘要】：目的探讨子宫内膜样腺癌转录因子Twist、乏氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)和上皮-间质转化(epithelial mesenchymal transition,EMT)表型分子E-钙粘素(E-cadherin)表达的临床意义及其相关性。方法选取山东省潍坊市人民医院2010-03-01-2013-10-31收治的58例子宫内膜样腺癌患者癌组织和23例正常子宫内膜组织作为研究对象,免疫组织化学方法检测Twist、HIF-1α和E-cadherin蛋白表达,分析其与患者临床病理因素的相关性。结果子宫内膜样腺癌组织Twist阳性表达率为55.2%,正常子宫内膜组织阳性表达率为4.3%,HIF-1α分别为60.3%和17.4%,E-cadherin分别为39.7%和100.0%,三者在子宫内膜样腺癌组织与正常子宫内膜组织中表达差异均有统计学意义,P值均0.05。Twist和HIF-1α表达增加及E-cadherin降低与子宫内膜样腺癌组织学肌层浸润程度和淋巴结转移有关(P0.05),Twist和HIF-1α表达增加与组织学分级和FIGO分期有关,P0.05。相关分析显示,Twist和HIF-1α蛋白表达均与E-cadherin表达存在负相关性(r=-0.687,P0.001;r=-0.496,P0.001),Twist和HIF-1α蛋白表达呈正相关,r=0.474,P0.001。结论 Twist和HIF-1α表达增加及E-cadherin表达降低均参与子宫内膜样腺癌发生发展和转移,Twist、HIF-1α和E-cadherin检测有助于评估子宫内膜癌恶性程度。
[Abstract]:Objective to investigate the clinical significance of expression of transcriptional factor Twist, hypoxia inducible factor-1 伪 -hypoxia inducible factor-1 伪 HIF-1 伪 and Ecadherin E-cadherin in endometrial adenocarcinoma. Methods 58 patients with endometrial adenocarcinoma and 23 normal endometrial tissues from 2010-03-01-2013-10-31 in Weifang people's Hospital of Shandong Province were selected as study subjects. The expression of Twistn HIF-1 伪 and E-cadherin protein were detected by immunohistochemistry. To analyze its correlation with clinicopathological factors. Results the positive expression rate of Twist in endometrial adenocarcinoma was 55.2 and that in normal endometrium was 4.3%. The positive rate of HIF-1 伪 was 60.3% and 17.4%, respectively. The expression of HIF-1 伪 in endometrial adenocarcinoma and normal endometrium was 39.7% and 100.0%, respectively. There were significant differences in the expression of 0.05.Twist and HIF-1 伪 and the decrease of E-cadherin in endometrioid adenocarcinoma. The increase of expression of HIF-1 伪 and 0.05.Twist 伪 was related to the degree of histologic myometrium invasion and lymph node metastasis in endometrial adenocarcinoma. The increase of the expression of HIF-1 伪 was related to histological grade and FIGO stage (P 0.05). Correlation analysis showed that there was a negative correlation between the expression of Twist and HIF-1 伪 protein and the expression of E-cadherin. There was a positive correlation between the expression of Twist protein and HIF-1 伪 protein. Conclusion the increased expression of Twist and HIF-1 伪 and the decrease of E-cadherin expression are involved in the development and metastasis of endometrial adenocarcinoma. The detection of HIF-1 伪 and E-cadherin in endometrial carcinoma is helpful to evaluate the malignancy of endometrial carcinoma.
【作者单位】：山东省潍坊市人民医院妇科;山东省潍坊市人民医院病理科;
【分类号】：R737.33

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