腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤以及对患者IL-6、IL-2和CRP的影响

发布时间：2018-06-07 00:43

本文选题：腹腔镜 + 子宫肌瘤剔除术　；参考：《中国内镜杂志》2017年11期

【摘要】：目的探讨腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤的效果。方法选取2015年2月-2016年2月在该院治疗的子宫肌瘤患者84例。其中,接受腹腔镜下子宫肌瘤剔除术患者51例(观察组),接受经腹子宫肌瘤剔除术患者33例(对照组),观察两组手术时间、术中出血量等情况,同时检测患者手术前后C反应蛋白(CRP)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、促卵泡生成素(FSH)、黄体生成素(LH)及窦状卵泡(AFC)的情况。结果观察组手术时间为(74.29±13.20)min,明显多于对照组(P0.05);观察组术中出血量、术后排气时间、住院天数及术中肌瘤剔除数分别为(105.39±32.04)ml、(17.40±2.31)h、(4.02±1.32)d和(6.02±1.32)个,明显少于对照组(P0.05);观察组术后CRP和IL-6分别为(25.20±5.32)mg/L和(38.04±10.11)ng/ml,明显低于对照组(P0.05),而IL-2为(46.13±13.10)ng/ml,明显高于对照组(P0.05);两组手术前后FSH、LH及AFC比较差异无统计学意义(P0.05);观察组术后并发症发生率为3.92%,明显低于对照组(P0.05);观察组术后复发率和妊娠率分别为21.56%和54.90%,与对照组比较差异无统计学意义(P0.05)。结论腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤是安全有效的,患者应激反应小,对卵巢功能无影响。
[Abstract]:Objective to investigate the effect of laparoscopic hysteromyomectomy in the treatment of uterine leiomyoma. Methods 84 patients with hysteromyoma treated in our hospital from February 2015 to February 2016 were selected. Among them, 51 cases were treated with laparoscopic hysteromyomectomy (observation group) and 33 cases with abdominal hysteromyomectomy (control group). The levels of C reactive protein (CRP), interleukin-2 (IL 2), interleukin 6 (IL 6), follicle stimulating hormone (FSH), luteinizing hormone (LH) and antral follicle (AFC) were also detected before and after operation. Results the operative time in the observation group was 74.29 卤13.20 minutes, which was significantly longer than that in the control group (P 0.05), the amount of blood lost during operation, the time of exhaust after operation, the days of hospitalization and the number of myoma removal in the observation group were 105.39 卤32.04ml / min, 17.40 卤2.31ml / min, 4.02 卤1.32d and 6.02 卤1.32d, respectively. CRP and IL-6 in the observation group were 25.20 卤5.32)mg/L and 38.04 卤10.11 ng / ml, respectively, which were significantly lower than those in the control group (P 0.05), while the IL-2 was 46.13 卤13.10 ng / ml, which was significantly higher than that in the control group (P 0.05). There was no significant difference in FSHLH and AFC between the two groups before and after operation, and there was no significant difference in postoperative complications between the two groups (P 0.05). The recurrence rate and pregnancy rate in the observation group were 21.56% and 54.90% respectively, and there was no significant difference between the two groups. Conclusion Laparoscopic hysteromyomectomy is safe and effective in the treatment of uterine leiomyoma.
【作者单位】：海南医学院第二附属医院妇科;
【分类号】：R737.33

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