人乳头状瘤病毒致卵巢癌的机制及其防治策略

发布时间：2018-06-08 07:50

本文选题：卵巢癌 + 人乳头状瘤病毒　；参考：《中华医院感染学杂志》2015年06期

【摘要】：卵巢癌是妇科常见的恶性肿瘤之一,发病率高,位居女性恶性肿瘤第3位,随着病情的发展,严重者甚至发生恶病质,严重威胁女性生命安全;纵观医学的发展进程,对于卵巢癌的研究并不在少数,目前仍存在着两种主要的假说,炎症假说和脑垂体促性腺激素假说,这表明卵巢癌与内分泌因素,病毒感染,遗传和家族因素,化学致癌及环境条件恶化因素等有很大关联;很多研究结果表明,感染和炎症是癌症发生发展的重要原因之一,炎症部位的细胞因子和趋化因子可引起细胞内染色体DNA发生损害,这些受损DNA的细胞存在于较高浓度的炎症细胞和不同生物因子的环境中发生失控性繁殖生长,最后导致其难以修复,而发展成为癌;而感染病原体是引发炎症的主要原因;该综述研究卵巢癌与HPV之间的联系,制定卵巢癌的防治策略,为卵巢癌的早期诊断以及治疗提供一定的临床基础。
[Abstract]:Ovarian cancer is one of the most common malignant tumors in gynecology. The incidence of ovarian cancer is high and it ranks third in female malignant tumors. With the development of the disease, cachexia even occurs in severe cases, which seriously threatens the life and safety of women. There are still two major hypotheses, the inflammation hypothesis and the pituitary gonadotropin hypothesis, which indicate that ovarian cancer is associated with endocrine factors, viral infection, heredity and familial factors. Chemical carcinogenesis and deterioration of environmental conditions are closely related; many studies have shown that infection and inflammation are one of the important causes of cancer occurrence and development. Cytokines and chemokines in inflammatory sites can cause damage to the DNA of chromosomes in cells that are found in higher concentrations of inflammatory cells and in environments with different biological factors, resulting in uncontrolled reproductive growth. Eventually, it became difficult to repair and developed into cancer; infection pathogens were the main cause of inflammation. This review studies the link between ovarian cancer and HPV, and formulates strategies for the prevention and treatment of ovarian cancer. To provide a clinical basis for the early diagnosis and treatment of ovarian cancer.
【作者单位】：河北医科大学第四医院检验科;河北医科大学第四医院输血科;
【基金】：河北省卫生厅基金资助项目(20130538)
【分类号】：R737.31

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