不影响宫腔形态的肌壁间子宫肌瘤对体外受精-胚胎移植妊娠结局的影响

发布时间：2018-06-10 05:22

本文选题：肌壁间子宫肌瘤 + 体外受精　；参考：《广东医学》2017年15期

【摘要】：目的探讨不影响宫腔形态的肌壁间子宫肌瘤对体外受精-胚胎移植(IVF-ET)妊娠结局的影响及随访观察。方法选取于生殖中心行IVF-ET,不孕合并超声检查示不影响宫腔形态的肌壁间子宫肌瘤患者91例,共行胚胎移植100个周期(观察组),抽取同期行IVF-ET治疗的单纯输卵管性不孕不合并子宫肌瘤患者100例(对照组)。对两组的一般情况、控制性超排卵情况、体外受精参数和妊娠结局进行回顾性对照分析。结果两组的基本情况差异无统计学意义。观察组与对照组的胚胎种植率(26.7%vs 30.5%)、临床妊娠率(48.0%vs51.0%)、自然流产率(20.8%vs 31.4%)、活产率(32.0%vs 28.0%)、早产率(9.4%vs 7.1%)差异无统计学意义(P0.05)。随访示观察组和对照组的剖宫产率为81.3%(26/32)和71.4%(20/28),差异无统计学意义(P0.05)。观察组剖宫产术中行肌瘤剔除者超过半数(11/20),剔除的肌瘤大小为2~5 cm,无出现术中大出血。结论不影响宫腔形态的肌壁间子宫肌瘤对IVF-ET临床妊娠结局无明显不良影响。
[Abstract]:Objective to investigate the effect of intramural myoma without influence on the pregnancy outcome of IVF-ETS in vitro fertilization-embryo transfer (IVF-et). Methods the IVF-ETS were performed in the reproductive center and 91 patients with intramural hysteromyoma who had no effect on the shape of uterine cavity were examined by ultrasonography. A total of 100 cycles of embryo transfer were performed (observation group, 100 cases of simple tubal infertility with uterine leiomyoma treated with IVF-ET at the same time) (control group). The general condition, controlled hyperovulation, in vitro fertilization parameters and pregnancy outcome were analyzed retrospectively. Results there was no significant difference in basic conditions between the two groups. There was no significant difference between the observation group and the control group in embryo implantation rate (26.7 vs 30.5), clinical pregnancy rate (48.0 vs 51.0), spontaneous abortion rate (20.8 vs 31.41%), live birth rate (32.0% vs 28.0%), premature delivery rate (9.4% vs 7.1%). The rate of cesarean section in the observation group and the control group was 81.3 / 32 and 71.4 / 20 / 28 respectively. There was no significant difference between the two groups (P 0.05). In the observation group, more than half of the patients underwent leiomyoma removal during cesarean section, and the size of the leiomyoma removed was 2 ~ 5 cm. There was no intraoperative hemorrhage. Conclusion there is no significant adverse effect of intramural myoma on the pregnancy outcome of IVF-ET.
【作者单位】：中山大学孙逸仙纪念医院生殖中心;
【基金】：广东省公益研究与能力建设专项资金项目(编号:2014A020213014) 广东省自然科学基金项目(编号:2015A030313086) 广东省医学科研基金立项项目(编号:A2015143)
【分类号】：R714.8;R737.33

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