职业与环境因素对孕唐氏综合征胎儿影响

发布时间：2018-06-10 17:09

本文选题：唐氏综合征 + 影响因素　；参考：《中国职业医学》2017年03期

【摘要】：目的分析职业与环境因素对孕唐氏综合征胎儿的影响。方法采用系统抽样法,以经绒毛、羊水或脐血穿刺诊断胎儿染色体G显带核型为唐氏综合征的97例孕妇为病例组,另选同期于同医院行上述检查为非唐氏综合征的373例孕妇为对照组。分析孕妇孕前接触职业和环境等因素对胎儿唐氏综合征发生的影响。结果孕妇年龄≥35岁者孕唐氏综合征胎儿的风险高于年龄35岁者(P0.01);孕妇职业接触含苯有机溶剂者孕唐氏综合征胎儿的风险高于无职业接触有害因素史者(P0.05);孕前或孕早期服用雌激素类药物者孕唐氏综合征胎儿的风险高于无药物使用史者(P0.05);孕前及孕早期房屋新装修或新家具使用史者孕唐氏综合征胎儿的风险高于无新装修史者(P0.01);孕前补充叶酸者孕唐氏综合征胎儿的风险低于无补充叶酸者(P0.05)。结论年龄、职业接触含苯有机溶剂和服用含雌激素类药物均是孕唐氏综合征胎儿的主要因素。
[Abstract]:Objective to analyze the influence of occupational and environmental factors on the fetus with Down's syndrome. Methods A total of 97 pregnant women with Down's syndrome were examined by means of systematic sampling, and 97 pregnant women with fetal chromosomal G-banding karyotype diagnosed by transvillus, amniotic fluid or umbilical cord blood puncture were selected as the case group. Another 373 pregnant women with non-Down syndrome in the same hospital were selected as control group. To analyze the influence of occupational and environmental factors on the occurrence of Down's syndrome in pregnant women before pregnancy. Results the fetal risk of Down's syndrome in pregnant women aged more than 35 years was higher than that in 35 years old, and that in pregnant women exposed to organic solvents containing benzene was higher than that in those with no history of harmful factors of occupational exposure. The fetal risk of Down's syndrome was higher than that of those with no history of drug use in early pregnancy, and the risk of pregnancy with Down's syndrome was higher than that with no history of decoration or furniture use before pregnancy and early pregnancy. The risk of pregnancy with Down's syndrome was lower than that without folic acid supplementation (P 0.05). Conclusion Age, occupational exposure to benzene-containing organic solvents and taking estrogenic drugs are the main factors of gestational Down syndrome fetus.
【作者单位】：山西医科大学公共卫生学院;广东省妇幼保健院;
【分类号】：R714.5

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