卵巢原发性黑色素瘤1例并文献复习

发布时间：2018-06-10 20:42

本文选题：卵巢肿瘤 + 原发性黑色素瘤　；参考：《临床与实验病理学杂志》2017年01期

【摘要】：目的探讨卵巢原发性黑色素瘤的临床病理学特征及鉴别诊断。方法对l例卵巢畸胎瘤进行大体检查、光镜观察及免疫组化EnVision法检测,并复习相关文献。结果卵巢肿物表面光滑,切开囊实性,部分区域有脂质及毛发,部分区域灰黑色、质软、朽脆。镜下肿瘤细胞中等大小,呈圆形及多边形,胞质红染、透亮,核圆形、卵圆形、豆瓣样,核仁明显,染色质粗糙,双核细胞、多核细胞及瘤巨细胞易见。肿瘤细胞排列成片状、巢状、腺泡状,光镜下瘤组织内见多处片状坏死,另见细胞内外多量黑色素颗粒。免疫表型:S-100、HMB-45、vimentin均阳性,CK、PLAP、Inhibin、CD45、desmin均阴性,Ki-67增殖指数约60%。结论卵巢原发性黑色素瘤是一种相对罕见的恶性肿瘤,其诊断需结合组织学形态及免疫表型。
[Abstract]:Objective to investigate the clinicopathological features and differential diagnosis of primary melanoma of ovary. Methods one case of ovarian teratoma was examined by light microscopy and envision immunohistochemical method. Results the surface of the ovarian tumor was smooth, the cyst was cut, the lipid and hair were found in some areas, and the areas were gray and black, soft and brittle. Under microscope, the tumor cells were of medium size, round and polygonal. The cytoplasm was red stained, transparent, round, oval, pea like, nucleolus obvious, rough chromatin, binuclear cells, multinucleated cells and tumor giant cells. The tumor cells were arranged in flake, nest and acinar shape. There were many pieces of necrosis and melanin granules inside and outside the tumor tissue under light microscope. Immunophenotypes of HMB-45 vimentin were all positive for CKP PLAPAPN, CD45 and desmin were negative for Ki-67 proliferative index (Ki 67). Conclusion Primary melanoma of ovary is a relatively rare malignant tumor and its diagnosis should be combined with histological morphology and immunophenotype.
【作者单位】：河南省南阳市第一人民医院病理科;
【分类号】：R737.31

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