女性高危型人乳头瘤病毒感染2501例调查

发布时间：2018-06-13 21:43

本文选题：高危型HPV + 广州地区　；参考：《南方医科大学学报》2015年10期

【摘要】：目的了解广州地区2013年和2014年女性高危型HPV感染情况,对该地区宫颈癌的预防和疫苗的开发提供指导。方法采用荧光PCR分型定性检测方法,对2501例来院就诊的女性患者或体检者宫颈分泌物中的13种高危型HPV特异性DNA核酸片段进行检测。结果 2013年和2014年高危型HPV总感染率分别为14.85%(146/983)、14.56%(221/1518),差异无统计学意义(χ2=0.041,P=0.839)。各年内各年龄段感染率差异亦无统计学意义(χ2=2.916,P=0.572;χ2=6.494,P=0.165)。2013年和2014年HPV亚型的总体构成比差异无统计学意义(χ2=11.872,P=0.452),2013年各亚型感染频次构成比从高到低依次为HPV52、16、58、56、39、51、68、59、31、35、18、33、45型,而2014年为HPV52、16、58、68、18、51、56、39、31、33、59、35、45型。结论广州地区女性高危型HPV感染率较高,各年龄段女性均应定期进行高危型HPV筛查,以预防和早期发现宫颈癌。开发新的多价疫苗或通用疫苗预防HPV感染,从而降低宫颈癌的发病率。
[Abstract]:Objective to investigate the prevalence of high risk HPV infection among women in Guangzhou in 2013 and 2014 and to provide guidance for the prevention of cervical cancer and the development of vaccine. Methods 13 high risk HPV-specific DNA nucleic acid fragments in cervical secretions of 2501 female patients or healthy controls were detected by fluorescence PCR typing. Results the total infection rate of high risk HPV in 2013 and 2014 was 14.85 / 986 / 983 / 14.56 / 1518, respectively. The difference was not statistically significant (蠂 ~ 2 / 0.041 / P ~ (0.839). There was no significant difference in the infection rate among different age groups (蠂 2 / 2.916 / P = 0.572; 蠂 ~ 26.494P = 0.165). There was no significant difference between 2013 and 2014 in the overall composition ratio of HPV subtype (蠂 ~ 2 / 11.872 / P ~ (0.452N). Conclusion the infection rate of high risk HPV in Guangzhou women is high. Women of all ages should be screened regularly in order to prevent and detect cervical cancer. Develop new multivalent or universal vaccines to prevent HPV infection, thereby reducing the incidence of cervical cancer.
【作者单位】：广州军区广州总医院检验科;
【基金】：广州市健康医疗协同创新重大专项(201400000004-1)
【分类号】：R737.33

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