子宫内膜癌患者血清人附睾上皮分泌蛋白4与鳞状细胞癌抗原水平变化及意义

发布时间：2018-06-14 12:52

  本文选题：子宫内膜癌 + 人附睾上皮分泌蛋白　； 参考：《山东医药》2015年45期

【摘要】：目的观察子宫内膜癌患者血清人附睾上皮分泌蛋白4(HE4)、鳞状细胞癌抗原(SCCAg)的水平变化,并探讨其临床意义。方法选取74例子宫内膜癌患者(子宫内膜癌组)、30例子宫内膜非典型增生患者(增生组)及同期体检健康的30例健康人群(对照组)作为研究对象,采用酶联免疫吸附法检测三组血清HE4、SCCAg,分析血清HE4、SCCAg与子宫内膜癌患者盆腔淋巴结转移及肌层浸润的关系。结果子宫内膜癌组血清HE4、SCCAg水平显著高于增生组、对照组(P均0.05),增生组与对照组血清HE4、SCCAg水平差异无统计学意义(P均0.05);在子宫内膜癌患者中,FIGO分期Ⅰ期、Ⅱ期者血清HE4、SCCAg水平显著低于Ⅲ期、Ⅳ期者(P均0.05),Ⅰ期与Ⅱ期、Ⅲ期与Ⅳ期者的血清HE4、SCCAg水平比较差异无统计学意义(P均0.05)。22例发生淋巴结转移子宫内膜癌者血清HE4、SCCAg水平均显著高于未发生淋巴结转移者(P均0.05)。不同浸润深度的子宫内膜癌患者血清HE4、SCCAg水平比较差异无统计学意义(P均0.05)。结论子宫内膜癌患者,尤其是发生淋巴结转移者血清HE4、SCCAg水平明显升高,检测血清HE4、SCCAg水平有助于子宫内膜癌的早期诊断及病情判断。
[Abstract]:Objective to observe the changes of serum levels of human epididymal epithelial secretory protein 4 (HE4) and squamous cell carcinoma antigen (SCCAG) in patients with endometrial carcinoma and to explore its clinical significance. Methods 74 cases of endometrial carcinoma (endometrial carcinoma group, 30 cases of endometrial atypical hyperplasia group) and 30 cases of healthy people (control group) were studied. Enzyme linked immunosorbent assay (Elisa) was used to detect the levels of serum HE4, SCCAg and their relationship with pelvic lymph node metastasis and myometrium infiltration in patients with endometrial carcinoma. Results the level of serum HE4CCAg in endometrial carcinoma group was significantly higher than that in proliferative group (P < 0.05), but there was no significant difference between proliferative group and control group (P < 0.05), and there was no significant difference between proliferative group and control group (P < 0.05). The serum levels of HE4 and SCCAg in stage 鈪，

本文编号：2017453