信号转导与转录激活因子4基因多态性与子痫前期的相关性研究

发布时间：2018-06-14 17:43

本文选题：子痫前期 + 信号转导与转录激活因子　；参考：《中山大学学报(医学科学版)》2017年05期

【摘要】：【目的】探讨信号转导与转录激活因子4(STAT4)基因rs10181656及rs16833431位点多态性与子痫前期相关性的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者(病例组)和179名健康孕妇(对照组)的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】(1)rs10181656位点在病例组中C/C、C/G及G/G基因型频率分别是35.96%、47.81%及16.23%,而对照组中的三种基因型的频率分别是46.37%、44.69%及8.94%,C/C、C/G及G/G基因型频率在病例组和对照组中分布具有统计学差异(P=0.031),C、G等位基因频率在病例组和对照组中分布具有统计学差异(P=0.009);(2)rs16833431位点:三种基因型和C、T等位基因频率在病例组和对照组的分布无统计学意义(P=0.508,0.461)。【结论】STAT4基因rs10181656位点多态性与子痫前期相关,而rs16833431位点多态性与子痫前期发病无关。
[Abstract]:[objective] to investigate the relationship between rs10181656 and rs16833431 polymorphism of signal transduction and transcription activator 4 (STAT4) gene and preeclampsia. [methods] 228 cases of eclampsia were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotypic frequencies of STAT4 gene rs10181656 C / G and rs16833431 C / T loci were 35.9646% and 16.23% respectively in patients with preclinical stage (case group) and 179 healthy pregnant women (control group). [results] the frequencies of C / C / C / G and G / G genotypes at C / C / C / G and G / G / G / G were 35.96% and 16.23%, respectively, in the control group. The frequencies of the three genotypes were 44.69% and 8.94%, respectively. There were statistical differences in the frequency of C / C / C / G and G / G genotypes between the case group and the control group. There were statistical differences in the allele frequencies of P0. 031 and Con G between the case group and the control group (P 0. 0092rs16833431): P0. 0092rs16833431 locus: P0. 0092rs16833431. There was no significant difference in the distribution of genotypes and CfT alleles between patients and controls. [conclusion] rs10181656 polymorphism of STAT4 gene is associated with preeclampsia. Rs16833431 locus polymorphism was not associated with preeclampsia.
【作者单位】：中山大学附属第一医院妇产科;
【基金】：广东省自然科学基金(S2011010003522)
【分类号】：R714.244

【相似文献】