PARP-1、Caspase-3在子宫内膜癌组织中的表达变化及意义

发布时间：2018-06-14 17:49

本文选题：子宫内膜癌 + 多聚ADP核糖聚合酶　；参考：《山东医药》2017年44期

【摘要】：目的探讨多聚ADP核糖聚合酶1(PARP-1)、半胱氨酸蛋白酶3(Caspase-3)在子宫内膜癌组织中的表达变化及其临床意义。方法收集子宫内膜癌组织60例份、正常子宫内膜组织20例份、子宫内膜增生组织20例份,采用免疫组化法检测各组织PARP-1、Caspase-3蛋白表达,分析子宫内膜癌组织PARP-1、Caspase-3表达与患者临床病理参数的关系及二者的相关性。结果子宫内膜癌组织、正常子宫内膜组织及子宫内膜增生组织PARP-1阳性表达率分别为73.33%、15.00%、45.00%,不同组织间PARP-1阳性表达率比较P0.05或0.01。子宫内膜癌组织、正常子宫内膜组织及子宫内膜增生组织Caspase-3阳性表达率分别为41.67%、85.00%、45.00%,正常子宫内膜组织Caspase-3阳性表达率高于子宫内膜癌组织及子宫内膜增生组织(P均0.01)。子宫内膜癌组织PARP-1阳性表达与患者的临床分期、分化程度、浸润深度均有关(P均0.05),与淋巴结转移无关(P0.05)。子宫内膜癌组织Caspase-3阳性表达与患者的临床分期、分化程度、浸润深度及淋巴结转移均无关(P均0.05)。子宫内膜癌组织PARR-1、Caspase-3阳性表达率呈负相关(r=-0.64,P0.01)。结论子宫内膜癌组织PARP-1表达升高、Caspase-3表达降低;PARP-1表达升高可能参与子宫内膜癌的发生与发展。
[Abstract]:Objective to investigate the expression and clinical significance of poly (ADP) ribosomal polymerase 1 (PARP-1) and cysteine protease 3 (Caspase-3) in endometrial carcinoma. Methods 60 cases of endometrial carcinoma, 20 cases of normal endometrium and 20 cases of endometrial hyperplasia were collected. To analyze the relationship between the expression of PARP-1 and Caspase-3 and the clinicopathological parameters in endometrial carcinoma. Results the positive expression rates of PARP-1 in endometrial carcinoma, normal endometrium and endometrial hyperplasia were 73.33 and 15.00, respectively. The positive rates of PARP-1 in different tissues were P0.05 or 0.01, respectively. The positive expression rates of Caspase-3 in endometrial carcinoma, normal endometrium and endometrial hyperplasia were 41.67 and 85.000.The positive rate of Caspase-3 in normal endometrial tissue was higher than that in endometrial carcinoma and endometrial hyperplasia (P 0.01). The positive expression of PARP-1 in endometrial carcinoma was correlated with clinical stage, degree of differentiation and depth of invasion (P 0.05), but not with lymph node metastasis (P 0.05). The positive expression of Caspase-3 in endometrial carcinoma was not correlated with clinical stage, degree of differentiation, depth of invasion and lymph node metastasis (P < 0.05). The positive expression rate of PARR-1 and Caspase-3 in endometrial carcinoma was negative correlation. Conclusion the higher expression of PARP-1 and the lower expression of Caspase-3 in endometrial carcinoma may be involved in the occurrence and development of endometrial carcinoma.
【作者单位】：蚌埠医学院第一附属医院;
【分类号】：R737.33

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