胚胎移植术后9和11d血清β-HCG值对妊娠结局的预测价值

发布时间：2018-06-14 23:06

本文选题：血清β-HCG + 胚胎移植　；参考：《南方医科大学学报》2015年07期

【摘要】：目的探讨胚胎移植术后9 d和11 d血清β人绒毛膜促性腺激素(β-HCG)水平对体外受精/胚胎移植(IVF-ET)或冻融复苏胚胎移植(FET)术后妊娠结局早期诊断的预测价值。方法选择2012年12月~2014年2月清远市人民医院生殖医学中心227个胚胎移植周期,胚胎移植后9 d和11 d检测血清β-HCG,并追踪妊娠结局,应用ROC曲线确定移植后9 d和11 d具有预测各种妊娠结局的最佳血清β-HCG界值。结果(1)将患者妊娠结局分为:未孕组(A)、生化妊娠组(B)和临床妊娠组(C);A、B、C3组移植后9 d和11 d血清β-HCG值组间比较差异显著(P0.01);(2)C组内分为单胎妊娠组(C1)、双胎妊娠组(C2)、早孕流产组(C3)、宫外孕组(C4)、宫内合并宫外孕组(C5);C1~C5五组9 d和11 d血清β-HCG值组间比较差异显著(P0.01);(3)移植后9 d,预测临床妊娠和双胎妊娠的β-HCG最佳阈值分别为49.05 U/L和105.15 U/L;移植后11 d,预测临床妊娠和双胎妊娠的β-HCG最佳阈值分别为51.2 U/L和241.75 U/L。结论胚胎移植后9 d及11 d的血清β-HCG定量可准确诊断是否妊娠,并可以预测生化妊娠、临床妊娠,及单双胎妊娠等不同妊娠结局。
[Abstract]:Objective to investigate the predictive value of serum 尾 -human chorionic gonadotropin (尾 -HCG) levels in early diagnosis of pregnancy outcome after in vitro fertilization / embryo transfer (IVF-ETT) or frozen-thawing resuscitation embryo transfer (FET) on the 9th and 11th day after embryo transfer. Methods 227 embryo transfer cycles were selected from December 2012 to February 2014 in the Reproductive Medicine Center of Qingyuan people's Hospital. Serum 尾 -HCG was detected 9 and 11 days after embryo transfer, and pregnancy outcome was tracked. The ROC curve was used to determine the best serum 尾 -HCG limit for predicting various pregnancy outcomes on the 9th and 11th days after transplantation. Results 1) the pregnancy outcome of the patients was divided into three groups: the non-pregnant group, the biochemical pregnancy group and the clinical pregnancy group. There were significant differences in serum 尾 -HCG between the clinical pregnancy group and the clinical pregnancy group on the 9th and 11th days after transplantation. There were significant differences in serum 尾 -HCG between the two groups: single pregnancy group, twin pregnancy group, and early pregnancy group. There were significant differences in serum 尾 -HCG between the two groups on 9 and 11 days after transplantation. The optimal threshold of 尾 -HCG for clinical pregnancy and twin pregnancy was 49.05 ul / L and 105.15 U / L, respectively. At the latter 11 days, the optimal thresholds of 尾 -HCG for clinical pregnancy and twin pregnancy were 51. 2 U / L and 241.75 U / L, respectively. Conclusion the serum 尾 -HCG on the 9th and 11th days after embryo transfer can accurately diagnose whether pregnancy is pregnant or not, and can predict different pregnancy outcomes such as biochemical pregnancy, clinical pregnancy and single twin pregnancy.
【作者单位】：南方医科大学南方医院妇产科生殖医学中心;清远市人民医院;广州医科大学附属第六医院生殖医学中心;
【分类号】：R714.8

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