多囊卵巢综合征患者口服炔雌醇环丙孕酮片致过敏反应

发布时间：2018-06-15 01:08

本文选题：临床药师 + 炔雌醇环丙孕酮片　；参考：《中国药师》2016年12期

【摘要】：目的:探讨临床药师在多囊卵巢综合征患者口服炔雌醇环丙孕酮片抗雄激素治疗中出现过敏反应的处理方法及药学监护。方法:临床药师通过综合分析患者过敏史及用药史,结合患者用药时间和不良反应的发生时间,判断所用药物与过敏反应的相关性,并对其后续治疗替代药物提出用药建议。结果:最终判定炔雌醇环丙孕酮片与此次不良反应的关联性评价为很可能,其中两种成分炔雌醇和醋酸环丙孕酮都不能排除为此次过敏反应的发生原因,建议选用屈螺酮炔雌醇片或含天然雌激素成分的口服避孕药进行后续替代治疗。结论:临床药师针对药物致过敏反应展开的病例分析及药学监护,有助于促进多囊卵巢综合征患者的个体化治疗,在保证用药安全,提高患者依从性方面发挥重要作用。
[Abstract]:Objective: to explore the methods and pharmacognostic monitoring of allergic reaction in patients with polycystic ovary syndrome (PCOS) after oral administration of ethylestradiol cyclopropofol tablets against androgen. Methods: the clinical pharmacists analyzed the allergic history and medication history of the patients, combined with the time of drug use and the occurrence time of adverse reactions, judged the correlation between the drugs used and the allergic reactions, and put forward some suggestions on the use of alternative drugs for the subsequent treatment. Results: it was possible to evaluate the association of ethylestradiol cyproprogesterone tablets with this adverse reaction, two of them, ethylestradiol and cyproprogesterone acetate, could not be excluded as the cause of the allergic reaction. It is suggested that oral contraceptive pills containing natural estrogen should be used for follow-up replacement therapy. Conclusion: case analysis and pharmacological monitoring of drug induced allergic reaction by clinical pharmacists are helpful to promote individualized treatment of patients with polycystic ovary syndrome and play an important role in ensuring safety of drug use and improving compliance of patients with polycystic ovary syndrome.
【作者单位】：第二军医大学长海医院药学部;
【分类号】：R711.75

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