养血当归胶囊联合米非司酮治疗围绝经期功能性子宫出血的疗效与安全性评价

发布时间：2018-06-15 04:21

本文选题：功能性子宫出血 + 围绝经期　；参考：《中国医院药学杂志》2017年07期

【摘要】：目的:观察养血当归胶囊联合米非司酮治疗围绝经期功能性子宫出血患者的有效性和安全性。方法:将72例围绝经期功能性子宫出血患者随机分为对照组和观察组,各36例。对照组患者服用米非司酮,观察组患者使用养血当归胶囊联合米非司酮治疗,对比两组治疗3个月后的临床疗效、血清激素水平、子宫内膜变化和对肝肾功能影响。结果:治疗组患者治疗总有效率为86.1%,对照组患者总有效率61.1%,有明显差异(P0.05);两组患者血清激素水平FSH、E_2、LH水平较治疗前均显著降低,治疗组血清激素水平下降优于对照组,有明显差异(P0.05)。两组患者子宫内膜均明显变薄,治疗组患者治疗后子宫内膜变化较对照组显著,有明显差异(P0.05)。两组患者治疗前后肝肾功能均无明显变化,无明显差异(P0.05)。结论:养血当归胶囊能够提高米非司酮治疗围绝经期功能性子宫出血患者的临床疗效,且未增加明显的无不良反应,值得临床研究推广。
[Abstract]:Objective: to observe the efficacy and safety of Yangxue Danggui capsule combined with mifepristone in the treatment of peri-menopausal functional uterine bleeding. Methods: 72 patients with functional uterine bleeding in perimenopausal period were randomly divided into control group and observation group with 36 cases each. The patients in the control group were treated with mifepristone, the patients in the observation group were treated with Yangxue Danggui capsule and mifepristone. The clinical effect, serum hormone level, endometrial changes and the effect on liver and kidney function were compared between the two groups after 3 months. Results: the total effective rate of treatment was 86.1 in the treatment group and 61.1 in the control group (P 0.05), the serum hormone level of the two groups was significantly lower than that before treatment, and the serum hormone level of the treatment group was better than that of the control group. There was a significant difference (P 0.05). The changes of endometrium in the treatment group were significantly higher than those in the control group (P 0.05). There was no significant difference in liver and kidney function between the two groups before and after treatment. Conclusion: Yangxue Danggui capsule can improve the clinical efficacy of mifepristone in the treatment of peri-menopausal functional uterine hemorrhage, and no significant increase in adverse reactions.
【作者单位】：安吉县中医院;
【分类号】：R711.52

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