膜联蛋白A5水平检测在妊娠中期胎儿宫内生长受限诊断中的应用

发布时间：2018-06-15 21:40

本文选题：膜联蛋白A + 妊娠中期　；参考：《广东医学》2015年04期

【摘要】：目的探讨妊娠中期羊水中膜联蛋白A5水平检测在胎儿宫内生长受限诊断中的应用价值。方法以137例孕15~24周孕妇为研究对象,行羊膜腔穿刺获取羊水标本,行ELISA检测确定膜联蛋白A5的水平。将最终出现胎儿宫内生长受限的资料(27例)与其余资料(110例)进行比较分析;同时以20 ng/L作为膜联蛋白A5水平分界线,比较水平内(92例)和水平外(45例)孕妇出现胎儿宫内生长受限的比例。结果胎儿宫内生长受限孕妇膜联蛋白A5水平为(26.54±2.77)ng/L,而其余孕妇为(19.42±2.21)ng/L;膜联蛋白A5水平超过20ng/L的孕妇其胎儿宫内生长受限发生率为26.1%(24/92),低于20 ng/L者其发生率为6.7%(3/45)。上述差异均有统计学意义(P0.05)。结论膜联蛋白A5水平与妊娠中期胎儿宫内生长受限存在一定的相关性,对于该蛋白水平超过20 ng/L的孕妇,需要重点预防胎儿宫内生长受限问题。
[Abstract]:Objective to investigate the value of amniotic fluid A5 in the midtrimester of amniotic fluid (amniotic fluid) in the diagnosis of fetal intrauterine growth restriction. Methods 137 pregnant women with 15~24 weeks were studied, amniocentesis was used to obtain amniotic fluid, and the level of annexin A5 was determined by ELISA detection. The data of fetal intrauterine growth restriction (27 cases) and the final appearance of fetal intrauterine growth restriction were investigated. The rest of the data (110 cases) was compared and analyzed; at the same time, 20 ng/L was used as the boundary of the membrane protein A5 level, and the ratio of intrauterine growth restriction in pregnant women (92 cases) and outside (45 cases) was compared. Results in pregnant women with intrauterine growth restriction, the level of annexin A5 was (26.54 + 2.77) ng/L, while the other pregnant women were (19.42 + 2.21) ng/L; The incidence of intrauterine growth restriction in pregnant women with protein A5 level exceeding 20ng/L was 26.1% (24/92) and 6.7% (3/45) was lower than that of 20 ng/L. The above differences were statistically significant (P0.05). Conclusion the level of annexin A5 is related to fetal intrauterine growth restriction in the mid-term pregnancy, and the protein level is over 20 ng/L. Pregnant women need to focus on preventing intrauterine growth restriction.
【作者单位】：广州医科大学附属深圳沙井医院产科;
【基金】：广东省深圳市宝安区科技计划项目(编号:20110488)
【分类号】：R714.5

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