HPV多重感染与宫颈病变关系的初步研究

发布时间：2018-06-15 23:04

本文选题：宫颈上皮内病变 + HPV多重感染　；参考：《中国妇产科临床杂志》2015年05期

【摘要】：目的探讨人乳头状瘤病毒(HPV)多重感染在不同级别宫颈病变中的分布情况及多重感染亚型间的相互作用。方法采用PCR-反向点杂交人乳头状瘤基因分型技术对300例(慢性宫颈炎症组121例、CIN158例、CIN2 42例、CIN3 20例、宫颈鳞癌组SCC 8例、正常对照组51例)就诊患者进行HPV分型检测。运用?2趋势检验比较HPV在不同病变中的总感染率、多重感染率,分析HPV亚型在多重感染中的分布及变化。结果正常对照组、慢性宫颈炎、CIN1、CIN2、CIN3、SCC组的HPV多重感染率分别为3.92%、9.92%、15.52%、19.05%、15.00%、12.50%。不同宫颈病变相对于正常对照组,多重感染率明显升高(P0.05),宫颈癌组多重感染率与正常对照组比较差异无统计学意义(P0.05);多重感染中以二重感染最常见,二重感染最常见的HPV亚型组合是HPV16+51型。结论 CIN1、CIN2、CIN3及宫颈癌中HPV的感染率均高于正常和宫颈慢性炎症组,高危型HPV多重感染(高危与高危)增加宫颈上皮内病变风险,但与宫颈癌的发生无明显相关性。
[Abstract]:Objective to investigate the distribution of multiple human papillomavirus (HPV) infection in different cervical lesions and the interaction between multiple infection subtypes. Methods HPV typing was performed in 300 patients (121 cases of chronic cervicitis group, 42 cases of CIN242 cases, 20 cases of cervical squamous cell carcinoma group, 8 cases of SCC group and 51 cases of normal control group) by using PCR- reverse dot hybridization technique. The total infection rate and multiple infection rate of HPV in different lesions were compared with the trend test. The distribution and change of HPV subtype in multiple infection were analyzed. Results the multiple infection rates of HPV in the control group and the chronic cervicitis group were 3.92 and 9.92, respectively. Compared with the normal control group, the multiple infection rate in different cervical lesions was significantly higher than that in the normal control group, while the multiple infection rate in the cervical cancer group was not significantly different from that in the normal control group. The most common combination of HPV subtypes for double infection is HPV16-51. Conclusion the infection rate of HPV in CIN1, CIN2, CIN3 and cervical cancer is higher than that in normal and chronic inflammation groups. High risk HPV multiple infection (high risk and high risk) increases the risk of cervical intraepithelial lesions, but has no significant correlation with the occurrence of cervical cancer.
【作者单位】：山东省千佛山医院产科;山东省交通医院妇产科;
【分类号】：R737.33

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