重庆市农村妇女高危型HPV感染状况分析

发布时间：2018-06-16 08:47

本文选题：宫颈肿瘤 + 人乳头瘤病毒　；参考：《重庆医学》2017年30期

【摘要】：目的分析重庆市农村妇女高危型人乳头瘤病毒(HPV)感染情况及其与宫颈病变的关系。方法 2016年1-4月选取重庆市万州区、永川区、巴南区、潼南区共20 000例农村妇女,以HPV基因分型检测对其进行宫颈癌的初筛。对HPV16、18型(+)者或其余12种HPV高危型(+)阴道镜检查异常者进行阴道镜定点活检。结果重庆市农村妇女高危型HPV感染阳性率为9.66%,不同年龄组的高危型HPV感染阳性率及不同高危型别HPV感染阳性率均有差异。高危型HPV感染阳性者中,宫颈上皮内瘤变(CIN)1发生率为2.33%,CIN2、CIN3及AIS发生率为1.35%,宫颈癌发生率为0.31%,不同年龄组各级别宫颈病变发生率差异无统计学意义。不同高危型别HPV感染者中,HPV16阳性者各级别宫颈病变发生率均最高,而其余12型HPV高危型别阳性者各级别宫颈病变发生率均最低,且差异有统计学意义。结论 HPV基因分型检测可提高宫颈癌的筛查效率,更适合在大规模人群中普查。
[Abstract]:Objective to analyze the high risk human papillomavirus (HPV) infection in rural women in Chongqing and its relationship with cervical lesions. Methods A total of 20 000 rural women were selected from Wanzhou District, Yongchuan District, Banan District and Tongnan District in Chongqing from January to April 2016. HPV genotyping was used to screen cervical cancer. Colposcopy biopsy was performed in the patients with HPV16 type 18 or other 12 high-risk types of HPV with abnormal colposcopy. Results the positive rate of high risk HPV infection in rural women in Chongqing was 9.66. The positive rate of high risk HPV infection and high risk type HPV infection were different among different age groups. Among the patients with high risk HPV infection, the incidence of CIN1 was 2.33%, the incidence of CIN2CIN3 and AIS was 1.35, and the incidence of cervical cancer was 0.31%. There was no significant difference in the incidence of cervical lesions among different age groups. The incidence of cervical lesions was the highest in the patients with HPV16 positive in different high risk types, but the lowest in the other 12 high risk HPV types, and the difference was statistically significant. Conclusion HPV genotyping can improve the screening efficiency of cervical cancer and is more suitable for screening in large-scale population.
【作者单位】：重庆市妇幼保健院妇女保健科;重庆市妇幼保健院信息科;
【分类号】：R737.33

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