宫颈病变患者HPV感染的流行病学调查及危险因素分析

发布时间：2018-06-18 01:03

本文选题：TCT + 高危人乳头瘤病毒　；参考：《中华医院感染学杂志》2017年22期

【摘要】：目的分析慈溪地区不同宫颈病变无症状患者HR-HPV感染的发病情况及其相关危险因素,为宫颈癌前病变的筛查及早期防治提供数据。方法选取2015年1月-2016年12月妇幼保健计划生育服务中心1425例已婚无症状妇女进行问卷调查,并行Cervista HPV HR和新柏氏液基薄层细胞学检测(TCT),分析宫颈病变、HR-HPV感染的发病情况及相关危险因素。结果 TBS分级正常范围(WNL)、意义不明的非典型鳞状细胞增生(ASCUS)、意义不明的非典型腺细胞(AGUS)、鳞状上皮细胞低度病变(LSIL)、非典型磷状上皮细胞不除外高度鳞状上皮细胞增生(ASCH)、鳞状上皮细胞高度病变(HSIL)、宫颈鳞癌(SCC)和腺癌(AC)分别占调查样本总数的93.33%、3.86%、0.28%、1.26%、0.56%、0.56%、0.07%和0.07%;WNL、ASCUS、AGUS、LSIL、ASCH、HSIL、SCC、AC中HR-HPV感染率依次为2.71%、41.82%、50%、94.44%、100%、87.5%、100%和100%;HRHPV在细胞学异常标本中的感染率62.1%显著高于细胞学正常标本2.7%(P0.001);初次性生活年龄≤20岁、吸烟、既往宫颈炎病史、流产次数1次、宫颈糜烂和宫颈触血是发生宫颈病变的独立危险因素(P0.05);性生活前后外阴清洗是发生宫颈病变的保护因素;初次性生活年龄≤20岁、吸烟、流产次数1次是发生HR-HPV感染的独立危险因素(P0.05);性生活前后外阴清洗和使用避孕套避孕是发生HR-HPV感染的保护因素(P0.05)。结论 Cervista HPV HR和TCT检测是慈溪地区无症状妇女宫颈癌初筛有效的常规方法,在流行病学筛查工作时,需重视引起宫颈病变及HPV感染发生的危险因素。
[Abstract]:Objective to analyze the incidence of HR-HPV infection and related risk factors of different cervical lesions and asymptomatic patients in Cixi, in order to provide data for screening and early prevention and control of cervical precancerous lesions. Methods 1425 cases of married women with asymptomatic women and child health care centers in December January 2015 were investigated by questionnaire and Cervist A HPV HR and new PAT'S liquid based thin layer cytology (TCT), analysis of cervical lesions, the incidence of HR-HPV infection and related risk factors. Results TBS graded normal range (WNL), untypical atypical squamous cell hyperplasia (ASCUS), untypical atypical glandular cell (AGUS), squamous cell low degree lesions (LSIL), atypical phosphorus like Epithelial cell proliferation (ASCH), squamous epithelial cell height (HSIL), cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) accounted for 93.33%, 3.86%, 0.28%, 1.26%, 0.56%, 0.56%, 0.07% and 0.07%, WNL, ASCUS, AGUS, LSIL, ASCH, HSIL, SCC, 2.71%, 41.82%, 50%, 94.44%, 100%, 8 7.5%, 100% and 100%; the infection rate of HRHPV in abnormal cytological specimens was 62.1% higher than that of normal cytology 2.7% (P0.001); primary sex age was less than 20 years old, smoking, past history of cervicitis, abortion times 1 times, cervical erosion and cervix touching blood were independent risk factors for cervical lesions (P0.05); vulvar cleaning before and after sex life was hair. The protective factors of cervical lesions, the first sex age less than 20 years, smoking and 1 times of abortion were independent risk factors for HR-HPV infection (P0.05); the cleaning of vulvar and the use of condom contraception before and after sex were the protective factors of HR-HPV infection (P0.05). Conclusion Cervista HPV HR and TCT detection are the cervix of asymptomatic women in Cixi The routine screening methods for cancer screening should pay attention to the risk factors of cervical lesions and HPV infection in epidemiological screening.
【作者单位】：慈溪市妇幼保健计划生育服务中心计划生育科;
【基金】：浙江省自然科学基金资助项目(LQ16H160018)
【分类号】：R737.33

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