绝经后妇女子宫内膜厚度与子宫内膜病变的关系的META分析

发布时间：2018-06-18 02:45

本文选题：子宫内膜厚度 + 子宫内膜癌　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:通过meta分析探讨绝经后妇女子宫内膜病变与子宫内膜厚度(小于或大于5mm)之间的关系。方法:计算机检索MEDLINE、Pub Med、EMBASE数据库。收集子宫内膜厚度和子宫内膜病变二者相关性的所有观察性研究。采用Rev Man 5.3版软件进行meta分析。分类变量使用比值比(OR)及95%置信区间进行合并估算。结果:检索出421篇相关文献,经剔除重复、个例分析及meta分析后,最终纳入5项研究。其中纳入的5项研究共包含2643例病人,其中1369例病人的子宫内膜厚度5mm,1274例病人的子宫内膜厚度5mm。汇总分析显示两组子宫内膜厚度的子宫内膜病变的发生率差异显著,如子宫内膜癌(OR 0.07,95%CI 0.01 0.33,P=0.0009,I2=83%),子宫内膜息肉(OR 0.28,95%CI 0.19 0.40,P0.00001,I2=0%),子宫内膜增生(OR 0.05,95%CI0.02 0.12,P0.00001,I2=67%),子宫内膜萎缩(OR 6.61,95%CI 0.75-58.73,P=0.09,I2=99%),但有一项结果无统计学意义,OR为0.23,95%CI为0.05-1.02。结论:在此次meta分析中,将子宫内膜5 mm作为临界值对于诊断所有常见子宫内膜病变具有高度敏感性。子宫内膜5mm的绝经后妇女,其子宫内膜病变如子宫内膜癌,子宫内膜息肉和子宫内膜增生的发病率均显著增高。本课题尚需要采用大样本绝经后出血病人的前瞻性研究资料进行更多的研究。
[Abstract]:Objective: to investigate the relationship between endometrial lesions and endometrial thickness (less or greater than 5 mm) in postmenopausal women by meta analysis. Methods: the database of MEDLINE Pub Medbin was searched by computer. To collect all the observational studies on the correlation between endometrial thickness and endometrial lesions. The software Rev Man 5.3 was used for meta analysis. The classification variables were estimated by ratio and 95% confidence interval. Results: 421 related literatures were retrieved. After eliminating duplication, case analysis and meta analysis, they were included in 5 studies. The five studies involved included 2643 patients, of whom 1369 had endometrial thickness of 5mm and 1274 patients with endometrial thickness of 5mm. The overall analysis showed that the incidence of endometrial lesions with endometrial thickness was significantly different between the two groups. If the OR of endometrial carcinoma is 0.07 / 95CI 0.01 / 0.33 / 0.0009 / I283, the OR of endometrial polyps is 0.28 / 95CI 0.19 / 0.40 / 0.00001C / I = 0.05 / 95 / CI0.02 0.12P0.00001 / I267A, endometrial atrophy OR 6.61 / 95CI 0.75-58.73P0.09 / 999, but there is no significant difference in one result: 0.2395 CI = 0.05-1.022nmnnngr (0.2395CI = 0.05-1.02P = 0.2395 CI = 0.05-1.02P = 0.2395 CI = 0.05-1.02P = 0.2395 CI = 0.2395 CI = 0.05-1.02P = 0.2395 CI = 0.2395 CI = 0.2395 CI = 0.05-1.02P = 0.2395 CI = 0.2395 CI = 0.2395 CI = 0.2395 CI = 0.05-1.02a). Conclusion: in this meta analysis, the critical value of 5 mm endometrium is highly sensitive to the diagnosis of all common endometrial lesions. In postmenopausal women with endometrial 5mm, the incidence of endometrial lesions such as endometrial carcinoma, endometrial polyps and endometrial hyperplasia was significantly increased. This study requires more prospective studies of large-sample postmenopausal bleeding patients.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.74

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