保妇康栓治疗混合性阴道感染的临床研究

发布时间：2018-06-18 21:04

  本文选题：保妇康栓 + 混合性阴道感染　； 参考：《实用妇产科杂志》2015年06期

【摘要】：目的:研究中成药保妇康栓调节阴道微生态平衡对治疗外阴阴道假丝酵母菌病(VVC)合并细菌性阴道病(BV)的临床意义。方法:采用前瞻性、随机、剂量组平行对照临床实验,将51例VVC合并BV的患者,分为保妇康栓组26例,甲硝唑联合硝酸咪康唑栓组(联合组)25例,分析两组患者在停药第7±3天和第28±5天的症状改善及实验室检查方面的变化,采用Nugent评分进行BV诊断及疗效评价。结果:第1次随访:保妇康栓组与联合组Nugent评分、减分率比较差异有统计学意义(P0.05),两组p H值、乳杆菌分级差异无统计学意义(P0.05);保妇康栓组与联合组患者外阴瘙痒、白带异味、白带增多不适症状比率较入组时均下降,但两组比较差异无统计学意义(P0.05);此外,两组患者VVC痊愈率(76.92%vs 88.00%)比较差异无统计学意义(P0.05),而BV痊愈率(38.46%vs 76.00%)差异有统计学意义(P0.05)。第2次随访:保妇康栓组较联合组p H值、Nugent评分及减分率差异均无统计学意义(P0.05);保妇康栓组15例患者的乳杆菌分级均达到Ⅰ级或Ⅱ级,恢复到正常水平,而联合组仍有2例未达到正常水平,但两组比较差异无统计学意义(P0.05);保妇康栓组患者外阴瘙痒、白带异味、白带增多不适症状比率较第1次随访时进一步下降,而联合组外阴瘙痒、白带异味、白带增多症状比例上升,其中联合组有2例外阴瘙痒、1例白带异味可能有复发情况发生,但两组比较差异不显著(P0.05);保妇康栓组与联合组患者BV均100%痊愈,保妇康栓组VVC复发率(6.67%)低于联合组(11.76%),两组比较差异无统计学意义(P0.05)。结论:保妇康栓能有效治疗VVC合并BV,能恢复阴道微生态平衡,作用较抗生素和缓、复发率低,值得在临床全面推广应用。
[Abstract]:Objective: to study the clinical significance of traditional Chinese patent medicine Baofukang suppository in regulating the balance of vaginal microecology in the treatment of vulvovaginal candidiasis with bacterial vaginosis (BV). Methods: Fifty-one patients with VVC combined with BV were divided into two groups: 26 cases in Baofukang suppository group and 25 cases in metronidazole combined with miconazole nitrate suppository group. The changes of symptoms and laboratory examination on the 7th 卤3rd and 28th 卤5 days after withdrawal were analyzed in the two groups. The BV diagnosis and curative effect were evaluated by Nugent score. Results: during the first follow-up, the Nugent score of Baofukang suppository group and the combined group were significantly lower than that of the control group (P 0.05). There was no significant difference in pH value and Lactobacillus grade between the two groups, and there was no significant difference between the two groups in the treatment of vulvar pruritus, leukorrhea, and abnormal smell of leucorrhea. In addition, there was no significant difference in the recovery rate of VVC between the two groups (76.92 vs 88.00), but there was no significant difference in the recovery rate of BV (38.46 vs 76.00). The second follow-up showed that there was no significant difference in pH value, Nugent score and score reduction rate between Baofukang suppository group and combined group, and 15 patients in Baofukang suppository group had Lactobacillus grade 鈪，

本文编号：2036864