活化白细胞粘附分子在卵巢浆液性肿瘤中的表达及意义

发布时间：2018-06-19 09:35

  本文选题：卵巢浆液性肿瘤 + 活化白细胞粘附分子　； 参考：《中国妇产科临床杂志》2017年03期

【摘要】：目的探讨活化白细胞粘附分子(ALCAM)在卵巢浆液性肿瘤中的表达及其意义。方法使用免疫组化法检测ALCAM在卵巢良性、交界性及恶性浆液性性肿瘤病灶中的表达。使用Elisa检测卵巢肿瘤患者术前血清中ALCAM浓度。结果卵巢良性、交界及恶性浆液性肿瘤患者血清均可检测到ALCAM,三组间浓度无统计学差异。ALCAM在卵巢良性、交界性、恶性肿瘤中的阳性表达率分别为:31.8%、28.5%及62.2%。良性与恶性肿瘤组间ALCAM蛋白表达率差异有统计学意义(P=0.001)。卵巢恶性肿瘤组织中ALCAM蛋白的表达与手术分期、是否有淋巴结转移及预后有相关性。ALCAM阳性组卵巢恶性肿瘤患者5年生存率为23.5%,而ALCAM阴性组为50.0%,二者之间差异有统计学意义(P=0.02)。结论卵巢恶性肿瘤组织中ALCAM表达增强为卵巢恶性肿瘤不良预后的指标。
[Abstract]:Objective to investigate the expression and significance of activated leukocyte adhesion molecule (ALCAM) in ovarian serous tumors. Methods the expression of ALCAM in ovarian benign borderline and malignant serous tumors was detected by immunohistochemistry. Serum ALCAM levels were measured by Elisa before operation in patients with ovarian tumors. Results ALCAM was detected in serum of patients with benign, borderline and malignant serous tumors. The positive expression rates of ALCAM in benign, borderline and malignant ovarian tumors were 28.5% and 62.2%, respectively. There was significant difference in ALCAM protein expression between benign and malignant tumor groups. The expression of ALCAM protein in ovarian malignant tumor tissues was correlated with the stage of operation, lymph node metastasis and prognosis. The 5-year survival rate of ovarian malignant tumor patients with positive ALCAM was 23.5g, while that of ALCAM negative group was 50.02.There was significant difference between the two groups. Conclusion the increased expression of ALCAM in ovarian malignant tumors is an indicator of poor prognosis of ovarian malignant tumors.
【作者单位】： 广东省深圳市宝安区人民医院妇科;
【基金】：深圳市宝安区科技计划社会公益项目(2014059)
【分类号】：R737.31
，

本文编号：2039432