卵巢交界性肿瘤保留生育功能手术的临床循证研究

发布时间：2018-06-21 02:19

  本文选题：卵巢交界性肿瘤 + 保留生育功能　； 参考：《吉林大学》2014年硕士论文

【摘要】：【目的】：系统评价保留生育功能手术治疗卵巢交界性肿瘤(Borderline ovarian tumor，BOT)的生存率、复发率和术后妊娠情况。 【方法】：计算机全面检索Pubmed、Medline、embase数据库等外文及CNKI、维普、万方、中国生物医学文献数据库等中文数据库，检索1990年1月1日至2014年3月1日期间发表的中英文文献，，对得到的文献分别进行评价、提取、剥除/引用、核对后，将纳入符合标准的前瞻性病例对照研究、回顾性病例对照研究，对同质性研究采用RevMan5.2.7软件进行Meta分析。 【结果】：共纳入14篇保留生育手术和非保留生育功能手术治疗卵巢交界性肿瘤生存率、复发率、生育情况比较的病例对照研究，共纳入患者2244例，其中948例（42%）行保留生育功能手术，14篇研究中1篇为前瞻性病例对照研究，13篇为回顾性回顾性病例对照研究。Meta分析结果表明，卵巢交界性肿瘤保留生育手术患者与非保留生育功能手术患者总体生存率增高，差异有统计学意义（OR=2.15，95%CI（1.09,4.23），P=0.03）。两组FIGOⅠ期患者生存率无明显差别，无统计学意义（OR=1.86，95%CI为（0.57,6.06），P=0.3）。保留生育功能手术复发率高于非保留生育功能手术，具有显著性统计学差异（OR=3.85，95%CI为（2.62,5.68），且P＜0.00001）。9篇临床病例对照研究记录了保留生育功能手术后的生育情况，其中4篇文献详细记录、分析了有生育要求并尝试怀孕和实际成功受孕患者的例数，并计算出总的妊娠率为55.6%。 【结论】保留生育功能手术虽然能增加卵巢交界性肿瘤患者的复发率，但不会降低患者的生存率，且维持了正常的妊娠、生育功能，增加了患者对生活的信心、提高了生存质量。
[Abstract]:[objective]: to evaluate systematically the survival rate, recurrence rate and postoperative pregnancy status of borderline ovarian tumor and BOT.Methods: a comprehensive computer search was conducted for Pubmedan Medlineembase database, CNKI, Weip, Wanfang, etc. The Chinese biomedical literature database and other Chinese databases were used to retrieve Chinese and English documents published between January 1, 1990 and March 1, 2014. The obtained documents were evaluated, extracted, stripped / quoted, and checked. Will include prospective case-control studies that meet the criteria, retrospective case-control studies, Meta-analysis was performed with Revman 5.2.7 software for homogeneity study. [results]: fourteen patients with ovarian borderline tumor were treated with reserved fertility surgery and non-reserved fertility surgery. In the case-control study of fertility comparison, a total of 2244 patients were included, of whom 948 were performed fertility preserving surgery. One of the 14 studies was a prospective case-control study and 13 were retrospective case-control studies. Meta-analysis showed that The overall survival rate of ovarian borderline tumor patients undergoing fertility preserving surgery was significantly higher than that of non-reserved fertility surgery patients, and the difference was statistically significant. There was no significant difference between the two groups in the survival rate of Figo 鈪

本文编号：2046751