冷冻胚胎移植前应用宫腔镜检查联合子宫内膜轻创术的意义

发布时间：2018-06-23 04:18

本文选题：冷冻胚胎移植 + 宫腔镜　；参考：《实用妇产科杂志》2015年07期

【摘要】：目的:探讨宫腔镜检查联合子宫内膜轻创术对冷冻胚胎移植(FET)后的临床妊娠结局的影响。方法:选择2013年3月至2014年3月行FET治疗的不孕患者165例为研究对象,其中在FET前行宫腔镜检查联合子宫内膜轻创术95例为宫腔镜组,直接行FET治疗的70例为对照组。比较两组的临床妊娠率、胚胎种植率和不良妊娠率(包括早期流产、胚胎停育、异位妊娠);并对宫腔镜组中宫腔镜检查结果正常与异常(子宫内膜炎、子宫内膜息肉及增生、宫腔粘连)患者的临床妊娠结局进行比较。结果:宫腔镜组的临床妊娠率(57.89%)、胚胎种植率(38.51%)明显高于对照组(42.86%、26.15%),差异有统计学意义(P0.05);两组不良妊娠率比较,差异无统计学意义(P0.05)。宫腔镜组中宫腔异常的发生率为50.53%,宫腔异常组中各种类型患者经治疗后的临床妊娠率、胚胎种植率分别与宫腔正常组比较,差异均无统计学意义(P0.05)。结论:宫腔镜检查联合子宫内膜轻创术可以提高FET周期的临床妊娠率、胚胎种植率。宫腔异常的患者经宫腔镜治疗后可改善子宫内膜的容受性。
[Abstract]:Objective: to investigate the effect of hysteroscopy combined with endometrial minimization on pregnancy outcome after frozen embryo transfer (FET). Methods: 165 infertile patients who were treated with FET from March 2013 to March 2014 were selected as study objects. Among them, 95 cases were treated with hysteroscopy combined with mild endometrial injury before FET, and 70 cases were treated directly with FET as control group. The clinical pregnancy rate, embryo implantation rate and abnormal pregnancy rate (including early abortion, fetal suspension, ectopic pregnancy) were compared between the two groups, and the results of hysteroscopy were normal and abnormal (endometritis, endometrial polyps and hyperplasia). Clinical pregnancy outcomes were compared in patients with intrauterine adhesions. Results: the clinical pregnancy rate (57.89%) and embryo implantation rate (38.51%) in hysteroscopy group were significantly higher than those in control group (42.86% 26.15%), the difference was statistically significant (P0.05), but there was no significant difference between the two groups (P0.05). The incidence of abnormal uterine cavity in hysteroscopy group was 50.53. The clinical pregnancy rate and embryo implantation rate of various types of patients in uterine cavity abnormal group after treatment were not significantly different from those of normal uterine cavity group (P0.05). Conclusion: hysteroscopy combined with minimally invasive endometrial surgery can improve the clinical pregnancy rate and embryo implantation rate of FET cycle. Hysteroscopy can improve endometrial receptivity in patients with abnormal uterine cavity.
【作者单位】：苏州大学附属第一医院生殖医学中心;
【基金】：苏州市“科教兴卫”青年科技基金资助(编号:kjxw2014005)
【分类号】：R714.8

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