子宫Ewing肉瘤1例并文献复习
本文选题:子宫肿瘤 + 尤因肉瘤 ; 参考:《临床与实验病理学杂志》2017年02期
【摘要】:目的探讨子宫原发性Ewing肉瘤的临床病理学特征。方法对1例子宫原发性Ewing肉瘤进行临床病理学及免疫表型分析,并通过FISH法检测EWSR1基因易位。结果肿瘤位于子宫,由小圆细胞构成,胞质稀少,细胞核圆形或卵圆形,核深染,染色质粗糙。核分裂象多见,呈巢状或小梁状排列。免疫表型:肿瘤细胞CD99、FLI-1、Syn、vimentin均呈弥漫阳性,FISH检测EWSR1基因易位。结论子宫原发性Ewing肉瘤是少见的小圆细胞恶性肿瘤,选择适当的免疫标志物CD99及FLI-1及FISH检测EWSR1基因易位可确诊。
[Abstract]:Objective to investigate the clinicopathological features of primary Ewing's sarcoma of the uterus. Methods A case of primary uterine Ewing's sarcoma was analyzed by clinicopathological and immunophenotypic analysis, and EWSR1 gene translocation was detected by fish method. Results the tumor was located in the uterus and consisted of small round cells. The cytoplasm was rare, the nucleus was round or oval, the nucleus was deep stained and the chromatin was rough. Mitoses are more common, nesting or trabecular arrangement. Immunophenotype: CD99 fli-1 and Synvimentin were all diffusely positive for detecting the translocation of EWSR1 gene by fish. Conclusion Primary uterine Ewing's sarcoma is a rare small round cell malignant tumor. The detection of EWSR1 gene translocation by CD99, FLI-1 and fish can be diagnosed by selecting the appropriate immunological markers CD99, FLI-1 and fish.
【作者单位】: 中国医科大学附属第六临床学院/鞍山市中心医院病理科;大连医科大学病理学教研室;福州迈新生物技术有限公司生产技术中心;
【分类号】:R737.33
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