泸县地区人类乳头状瘤病毒感染的分子流行病学调查

发布时间：2018-06-24 23:35

本文选题：四川泸县地区 + 人类乳头状瘤病毒(HPV)　；参考：《现代预防医学》2015年05期

【摘要】：目的调查分析四川泸县地区不同宫颈病变患者人类乳头状瘤病毒(Human Papilloma Virus,HPV)感染情况,为该地区HPV感染的预防和宫颈癌筛查防治提供参考。方法采用基因芯片技术对宫颈液基细胞技术所获宫颈细胞及手术切除宫颈石蜡组织进行基因分型检测,统计HPV各基因型的感染及分布情况。结果 275例宫颈病变样本中,HPV检出阳性率为53.09%(146/275),其中高危感染占84.25%(123/146),低危感染占30.14%(44/146),单一感染占88.36%(129/146),混合型占11.64%(17/146)。高危型中最常见前6种亚型依次为:HPV16、39、58、52、18和66,低危型中最常见前4种亚型依次为:HPV11、6、54和44。总感染率中表现出两个年龄分布高峰,20~29岁和50~70岁年龄段。高危型感染在各年龄段没有显著差异,低危型感染主要集中在20~29岁,显著高于其余各年龄段(P0.01)。结论泸县地区不同程度宫颈病变患者有较高的高、低危型HPV感染率,具有较强的区域和年龄段分布特点。本研究可为该地区HPV感染的预防和宫颈癌筛查防治及疫苗使用等提供重要的参考依据。
[Abstract]:Objective to investigate and analyze the human papilloma virus (HPV) infection in patients with different cervical lesions in Luxian, Sichuan Province, and to provide a reference for the prevention of HPV infection and the screening and prevention of cervical cancer. Methods the genotypes of cervical cells obtained by cervical liquid-based cell technique and paraffin tissue of cervix surgically resected were detected by gene chip technique, and the infection and distribution of HPV genotypes were analyzed. Results the positive rate of HPV was 53.09% (146 / 275) in 275 cases of cervical lesions, including high risk infection (84.25%), low risk infection (30.14%) (44 / 146), single infection (88.36% (129 / 146) and mixed type (11.64% (17 / 146). The most common 6 subtypes of high risk type were: 1 / HPV1639 / 58 / 522 / 18 and 66, respectively, and the most common four subtypes of low risk type were: 1 / HPV11 / 654 and 44 / 44, respectively. In the total infection rate, the two age distribution peaks were 20 ~ 29 years old and 50 ~ 70 years old. There was no significant difference in high risk type infection in all age groups, and the low risk type infection was mainly concentrated in 20 to 29 years old, which was significantly higher than that in other age groups (P0.01). Conclusion there are high and low risk HPV infection rates in patients with cervical lesions of different degrees in Luxian area, and they have strong regional and age distribution characteristics. This study can provide important reference for HPV infection prevention, cervical cancer screening and vaccine use in this area.
【作者单位】：泸州医学院附属医院病理科;泸县人民医院病理科;
【基金】：泸州医学院自然科学基金(55) 泸州医学院博士启动基金(2011204) 泸州市科技局科技计划项目(2013-S-47(14/20)) 泸州医学院-四川省科技厅联合资助项目(14JC0161)
【分类号】：R737.33

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