子宫内膜癌患者组织miR-95表达与临床病理特征及预后的关系

发布时间：2018-06-24 23:59

本文选题：子宫内膜癌 + miR-　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨子宫内膜癌患者组织miR-95表达与临床病理特征及预后的关系。方法子宫内膜癌患者手术标本90例,以癌旁组织标本作为正常对照,应用原位杂交(ISH)及实时荧光定量PCR(qRT-PCR)检测子宫内膜癌患者组织及癌旁组织中miR-95的表达水平,分析miR-95表达与子宫内膜癌临床病理特征及患者预后的关系。结果与癌旁组织相比,子宫内膜癌组织中的miR-95表达水平较高(P0.05);在子宫内膜癌组织中,miR-95的表达在有无盆腔淋巴结转移、不同肌层浸润深度及国际妇产科联盟(FIGO)分期中存在显著差异(P0.05),而在不同年龄段、是否绝经、不同肿瘤类型、病理类型以及分化程度中无统计学差异(P0.05)。Kaplan-Meier生存分析显示,miR-95表达越高患者生存率越低(P0.05)。结论 miR-95可作为子宫内膜癌预后预测及治疗的潜在靶点。
[Abstract]:Objective to investigate the relationship between miR-95 expression and clinicopathological features and prognosis of endometrial carcinoma. Methods the expression of miR-95 in endometrial carcinoma tissues and adjacent tissues was detected by in situ hybridization (ish) and real-time fluorescence quantitative PCR (qRT-PCR). To analyze the relationship between miR-95 expression and clinicopathological features and prognosis of endometrial carcinoma. Results the expression of miR-95 in endometrial carcinoma was higher than that in paracancerous tissue (P0.05), and the expression of miR-95 in endometrial carcinoma was found in pelvic lymph node metastasis. There were significant differences in the depth of myometrial infiltration and in the International Federation of Obstetrics and Gynecology (Figo) stages (P0.05). There was no statistical difference in pathological type and differentiation (P0.05) .Kaplan-Meier survival analysis showed that the higher the expression of miR-95, the lower the survival rate (P0.05). Conclusion miR-95 may be a potential target for prognosis prediction and treatment of endometrial carcinoma.
【作者单位】：郑州人民医院妇产科;安徽中医药大学第一附属医院妇产科;河南中医药大学第三附属医院妇科;
【分类号】：R737.33

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