绝经后女性激素替代治疗与尿失禁关系的Meta分析

发布时间：2018-06-25 12:56

本文选题：雌激素替代疗法 + 尿失禁　；参考：《中国全科医学》2016年11期

【摘要】：目的系统评价绝经后女性激素替代治疗与尿失禁的关系。方法全面检索Pub Med、EMBase、Cochrane Library、CNKI、万方电子期刊,检索时间均为建库至2015年8月,纳入激素替代治疗与尿失禁关系的随机对照试验,并进行文献质量评价和资料提取,提取研究对象的基本特征、试验设计细节、治疗方案、有效例数,对同质研究进行Meta分析。结果共纳入8项研究,6项为高质量研究,2项为低质量研究。Meta分析结果表明:绝经后健康女性使用激素替代治疗会导致尿失禁的发生率增加〔RR=1.48,95%CI(1.30,1.68),P0.000 01〕;绝经后存在尿失禁的患者在使用激素替代治疗后尿失禁症状未见明显好转〔RR=0.98,95%CI(0.76,1.26),P=0.87〕。结论绝经后的健康女性使用激素替代治疗后尿失禁的发生率会显著增加,而存在尿失禁的绝经后女性在使用激素替代治疗后不会改善尿失禁症状。
[Abstract]:Objective to evaluate the relationship between hormone replacement therapy and urinary incontinence in postmenopausal women. Methods Pub Meden EMBase Cochrane Library CNKI (Wanfang Electronic Journal) was searched in a randomized controlled trial of the relationship between hormone replacement therapy and urinary incontinence, which was established until August 2015, and the literature quality was evaluated and the data were extracted. Extraction of the basic characteristics of the study, experimental design details, treatment scheme, effective number of cases, meta-analysis of homogeneous research. Results A total of 8 studies including 6 high quality studies and 2 low quality studies. Meta-analysis results showed that the incidence of urinary incontinence was increased in postmenopausal healthy women using hormone replacement therapy (RRN 1.4895 CI (1.301.68) P 0.00001). The symptoms of urinary incontinence in postmenopausal patients with urinary incontinence did not improve significantly after hormone replacement therapy (RRN 0.9895 CI (0.761.26) P 0.87). Conclusion the incidence of urinary incontinence in postmenopausal healthy women increased significantly after hormone replacement therapy, but the postmenopausal women with urinary incontinence did not improve the symptoms of urinary incontinence after hormone replacement therapy.
【作者单位】：北京大学第一医院全科医学教研室;北京大学第一医院呼吸科;
【分类号】：R711.59

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