海南地区黎、汉族女性高危型人乳头瘤病毒感染及其宫颈病变情况的比较研究

发布时间：2018-06-26 12:44

本文选题：黎族 + 汉族　；参考：《现代预防医学》2017年03期

【摘要】：目的探讨海南黎、汉族女性高危型人乳头瘤病毒(High-risk human papillomavirus,HR-HPV)的感染及致病特点。方法以第二代杂交捕获法(Hybrid Capture 2,HC2)检测199例黎族与397例汉族女性宫颈脱落细胞的HR-HPV DNA,对比黎、汉族病毒感染与年龄及宫颈病变的关系。结果(1)总体上HR-HPV感染率(分别26.63%与26.45%)及病毒载量在黎、汉族间无明显差异(均P0.05);黎族感染率与年龄正相关(P0.05),载量随年龄增长呈倒"V"字形分布,而汉族样本HR-HPV感染率及病毒载量的年龄变化趋势均与黎族相反。(2)黎、汉族样本HR-HPV感染率在不同宫颈病变中的变化相似,同级别宫颈病变者的病毒载量没有民族差异(均P0.05)。结论海南黎族HR-HPV感染的年龄变化特点有别于当地汉族,暂未发现病毒的致病性存在民族差异。
[Abstract]:Objective to investigate the infection and pathogenicity of high risk human papillomavirus (HR-HPV) in women of Li and Han nationality in Hainan. Methods the HR-HPV DNA of cervical exfoliated cells of 199 Li and 397 Han women were detected by Hybrid capture 2HC2 method. Results (1) overall HR-HPV infection rate (26.63% vs 26.45%) and viral load were not significantly different between Li and Han nationality (P0.05). The age variation trend of HR-HPV infection rate and viral load in Han nationality samples were opposite to that of Li nationality. (2) the infection rate of HR-HPV infection in Han nationality samples was similar in different cervical lesions, and there was no national difference in virus load in the same grade of cervical lesions (P0.05). Conclusion the age variation of HR-HPV infection in Li nationality of Hainan is different from that of local Han nationality.
【作者单位】：海南医学院附属医院检验科;淮安市妇幼保健院医学遗传中心;海南医学院热带医学与检验医学院;
【基金】：海南省卫生厅科研立项项目(琼卫2013支助-055号) 国家级大学生创新创业训练计划项目(201311810040) 海南医学院大学生创新性计划项目(HYCX201206)
【分类号】：R737.33

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