炎症因子的表达与子宫内膜癌的关系探讨

发布时间：2018-06-26 14:15

本文选题：子宫内膜癌 + 炎症　；参考：《广西医科大学》2014年硕士论文

【摘要】：目的：检测正常子宫内膜、不典型增生子宫内膜及子宫内膜癌中炎症因子NF-κB及COX-2的表达情况,分析其与子宫内膜癌临床病理特征之间的关系,以探讨它们在子宫内膜癌发生、发展及预后评估中的作用。方法：采用免疫组化SP法,检测正常子宫内膜、不典型增生子宫内膜和子宫内膜癌中NF-KB/p65和COX-2的表达水平,比较它们在不同子宫内膜组织中表达的差异,分析其表达与子宫内膜癌FIGO分期、组织学分级、肌层浸润深度、淋巴结有无转移及病理类型的关系。结果：从正常子宫内膜、不典型增生子宫内膜到子宫内膜癌,NF-κB/p65和COX-2的阳性表达率逐渐增高,p65在三组间表达差异有统计学意义(P0.05),而COX-2的表达差异无统计学意义(P0.05)。在子宫内膜癌中,p65表达与组织学分级有关,与FIGO分期、肌层浸润深度、淋巴转移和病理类型无相关；COX-2与FIGO分期、组织学分级、肌层浸润深度、淋巴转移和病理类型均无相关。结论：NF-κB/p65的活化可能是子宫内膜癌的早期事件,与子宫内膜癌的发生有关。在子宫内膜癌中,NF-κB/p65的表达与组织分化程度有关,提示NF-κB/p65可能与子宫内膜癌的恶性程度相关,可能成为判断预后的指标之一。COX-2在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌中的表达率差别无统计学意义。在子宫内膜癌中,COX-2的表达与FIGO分期、组织学分级、肌层浸润深度、淋巴结转移及组织病理类型等无明显关系。
[Abstract]:Objective: to detect the expression of inflammatory factors NF- 魏 B and COX-2 in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma, and analyze the relationship between them and clinicopathological features of endometrial carcinoma. The role of development and prognostic evaluation. Methods: immunohistochemical SP method was used to detect the expression of NF-KB / p65 and COX-2 in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma. The relationship between expression and Figo stage, histological grade, depth of myometrium invasion, lymph node metastasis and pathological type of endometrial carcinoma were analyzed. Results: from normal endometrium, atypical hyperplasia endometrium to endometrial carcinoma, the positive rate of NF- 魏 B / p65 and COX-2 increased gradually (P0.05), but the difference of COX-2 expression was not significant (P0.05). The expression of p65 in endometrial carcinoma was related to histological grade, but not to Figo stage, depth of myometrial invasion, lymphatic metastasis and pathological type. There was no correlation between COX-2 and Figo stage, histological grade, depth of myometrial invasion, lymphatic metastasis and pathological type. Conclusion the activation of 10% NF- 魏 B / p65 may be an early event in endometrial carcinoma and may be related to the occurrence of endometrial carcinoma. The expression of NF- 魏 B / p65 in endometrial carcinoma is related to the degree of tissue differentiation, suggesting that NF- 魏 B / p65 may be associated with the malignancy of endometrial carcinoma, and may be one of the prognostic markers of COX-2 in normal endometrium. There was no significant difference in the expression rate between atypical hyperplasia endometrium and endometrial carcinoma. The expression of COX-2 in endometrial carcinoma was not correlated with Figo stage, histological grade, depth of myometrial invasion, lymph node metastasis and histopathological type.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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