雌激素代谢酶CYP1A1及COMT基因多态性与子宫肌瘤相关性研究

发布时间：2018-06-27 05:49

本文选题：子宫肌瘤 + 细胞色素P　；参考：《实用妇产科杂志》2015年02期

【摘要】：目的:探讨雌激素代谢酶CYP1A1和COMT基因多态性与子宫肌瘤发生的关系。方法:应用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术,对100例子宫肌瘤患者和100例对照组人群CYP1A1基因Msp I位点多态和COMT基因外显子4密码子158(G-A)多态性进行分析。结果:1两组均存在CYP1A1基因Msp I位点多态,但两组基因型TT、TC、CC频率和等位基因T、C频率的比较差异均无统计学意义(P0.05);2两组均存在COMT基因G-A多态,但两组基因型GG、GA、AA频率和等位基因G、A频率的比较差异均无统计学意义(P0.05)。结论:CYP1A1基因Msp I位点多态性和COMT基因外显子4密码子158(G-A)多态性与子宫肌瘤发病风险无相关性。
[Abstract]:Objective: to investigate the association of CYP1A1 and COMT gene polymorphisms with uterine leiomyogenesis. Methods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the polymorphism of CYP1A1 gene MSP I locus and COMT gene exon 4 codon 158 (G-A) in 100 patients with uterine leiomyoma and 100 controls. Results the polymorphism of CYP1A1 gene MSP I was found in the two groups, but there was no significant difference in the frequency of TCCC and TnC between the two groups (P0.05). The G-A polymorphism of COMT gene was found in both groups (P0.05). However, there was no significant difference between the two groups in the frequency of GGG GA-AA and the frequency of allele GGA-A (P0.05). Conclusion there is no correlation between the polymorphism of MspI locus of CYP1A1 gene and codon 158 (G-A) polymorphism of COMT gene and the risk of uterine leiomyoma.
【作者单位】：四川省成都市第二人民医院;中国医学科学院输血研究所;
【基金】：四川省卫生厅科研基金资助项目(编号:070375)
【分类号】：R737.33

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