妊娠4～9周不同妊娠结局者血清相关激素水平的变化

发布时间：2018-06-27 22:02

本文选题：人绒毛膜促性腺激素 + 孕酮　；参考：《河北联合大学》2014年硕士论文

【摘要】：目的探讨妊娠4～9周妇女血清人绒毛膜促性腺激素（human chorionicgonadotropin，hCG）、孕酮（progesterone，P）、雌二醇（estrone，E2）及睾酮（testosterone，T）等4种激素水平在不同妊娠结局组的差异，并分析该4种激素随孕周增长的变化。方法选择早期宫内单胎妊娠妇女314例进行问卷调查，无内外科合并症，随访至孕3月末，采用化学发光分析法检测所有孕妇空腹血清hCG、P、E2及T水平，根据妊娠结局、孕周及临床症状进行分组，用SPSS16.0软件对结果进行统计分析。结果1314例早期宫内单胎妊娠妇女，正常妊娠者167例（正常妊娠组，53.18%），异常妊娠者147例（异常妊娠组，46.82%）。异常妊娠组中先兆流产者102例（先兆流产组，69.39%），难免流产者29例（难免流产组，19.73%），稽留流产者16例（稽留流产组，10.88%）。早孕期妊娠丢失者占妊娠总数的14.33%（45/314）。2正常妊娠组的血清HCG、E2及T水平与孕周均呈正相关（血清HCG：r=0.57，P=0.00；血清E2：r=0.62，P=0.00；血清T：r=0.24，P=0.00），血清P水平与孕周无相关性（r=0.15，P=0.06）。3正常妊娠组的血清P水平95%参考值范围为（81.98～90.50）nmol/L，血清E2水平95%参考值范围为（2826.2～3383.0）pmol/L。4相同孕周，，正常妊娠组的血清E2水平均高于异常妊娠组（P均0.05）。5并联法指标联合检测4种激素水平对诊断异常妊娠的灵敏度可高达94.83%。结论1正常妊娠组的血清HCG、E2及T水平与孕周呈正相关，但血清P水平处于相对恒定水平，不随孕周发生变化。2妊娠4～9周，正常妊娠组的血清E2水平均高于异常妊娠组。3联合检测血清hCG、E2、P及T水平更有利于预测早孕期的妊娠结局。
[Abstract]:Objective to investigate the differences of serum levels of human chorionic gonadotropin (hCG), progesterone (P), estradiol (E 2) and testosterone (T) in women with 4 weeks of gestation in different pregnancy outcome groups, and to analyze the changes of these four hormones with gestational weeks. Methods A questionnaire survey was conducted in 314 women with early intrauterine single pregnancy. All pregnant women were followed up until the third trimester of pregnancy. The fasting serum levels of hCGG PnP E 2 and T were measured by chemiluminescence assay, according to the outcome of pregnancy. Gestational age and clinical symptoms were divided into groups and the results were statistically analyzed by SPSS 16.0 software. Results among 1314 cases of early intrauterine single pregnancy, 167 cases were normal pregnancy (53.18% of normal pregnancy group) and 147 cases of abnormal pregnancy group (46.82% of abnormal pregnancy group). There were 102 cases of threatened abortion (69.39%), 29 cases of inevitable abortion (19.73%) and 16 cases of missed abortion (10.88%) in abnormal pregnancy group. (2) the serum levels of HCG E 2 and T in normal pregnancy group were positively correlated with gestational weeks (HCG: r 0.57 P 0.00; E 2: r 0.62 P 0.00; E 2: r 0.62 P 0.00). There was no correlation between serum P level and gestational week (r = 0.15). 3 the reference range of serum P level in normal pregnancy group was (81.98 / 90.50) nmol / L, and the reference range of serum E _ 2 level 95% was (2826.2383.0) pmol / L.4 for the same gestational week. The serum E2 level in normal pregnancy group was significantly higher than that in abnormal pregnancy group (P 0.05). The sensitivity of combined detection of four hormones in abnormal pregnancy was 94.83%. Conclusion (1) the levels of serum HCG E 2 and T in normal pregnancy group were positively correlated with gestational week, but the serum P level was relatively constant and did not change with gestational week .2 at 4 weeks of gestation. The level of serum E2 in normal pregnancy group was higher than that in abnormal pregnancy group. Combined determination of serum hCGE2P and T levels was helpful to predict pregnancy outcome in early pregnancy.
【学位授予单位】：河北联合大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.1

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