妊娠糖尿病孕妇α-L-岩藻糖苷酶检测价值及其与总胆汁酸的相关性

发布时间：2018-06-27 22:15

  本文选题：妊娠糖尿病 + α-L-岩藻糖苷酶　； 参考：《实用医学杂志》2017年22期

【摘要】：目的探讨α-L-岩藻糖苷酶(AFU)在妊娠糖尿病(GDM)中的检测价值以及AFU与血总胆汁酸(TBA)的相关性。方法 360例孕妇于孕12周前测量身高、体质量、腰围及血压;孕24~28周行口服葡萄糖耐量试验(OGTT),检测0、60及120 min血糖及胰岛素、血常规及生化指标,确认GDM患者,按年龄及体质量指数匹配对照组。对二组进行比较并作统计分析。结果 GDM组AFU水平高于糖耐量正常(NGT)组,对GDM的诊断有参考价值且与餐后1 h血糖相关;GDM组直接胆红素低于NGT组;校正肝功能及糖化血红蛋白后,AFU与TBA相关。结论孕期AFU水平对GDM的诊断有参考价值,主要与餐后1 h血糖水平相关;AFU水平升高同时伴有直接胆红素下降、TBA及碱性磷酸酶水平增加,提示GDM患者胆道功能呈活跃状态。
[Abstract]:Objective to investigate the value of 伪-L-fucosidase (AFU) in the detection of gestational diabetes mellitus (GDM) and the correlation between AFU and total bile acid (TBA). Methods the body height, body mass, waist circumference and blood pressure were measured in 360 pregnant women before 12 weeks of gestation, and oral glucose tolerance test (OGTT) was performed at the 28th week of gestation. Blood glucose and insulin, blood routine and biochemical indexes were detected at 60 and 120 min. The control group was matched according to age and body mass index. The two groups were compared and statistically analyzed. Results the level of AFU in GDM group was higher than that in NGT group, which had reference value in diagnosis of GDM and was lower than that in NGT group after 1 h postprandial blood glucose, and there was a correlation between AFU and TBA after correcting liver function and glycosylated hemoglobin. Conclusion the level of AFU in pregnancy is valuable for the diagnosis of GDM, which is mainly related to the elevation of AFU level at 1 h postprandial and accompanied by the increase of direct bilirubin decreasing TBA and alkaline phosphatase, indicating that the biliary tract function of GDM patients is active.
【作者单位】： 上海交通大学附属第六人民医院南院内分泌科;上海交通大学附属第六人民医院南院妇产科;
【基金】：上海市卫生和计划生育委员会科研项目(编号:201640272)
【分类号】：R714.256
，

本文编号：2075457