凝血功能4项、FDP、D-Dimer检测在诊断产后出血中的临床应用

发布时间：2018-06-28 19:29

本文选题：凝血功能项 + 纤维蛋白纤维蛋白原降解物　；参考：《重庆医学》2015年17期

【摘要】：目的探讨凝血功能4项、纤维蛋白原降解产物(FDP)、D-二聚体(D-Dimer)检测在产后出血诊断中的临床应用。方法将46例产后出血(出血量大于或等于500mL)孕妇作为产后出血组,另外50例出血量正常(出血量小于500mL)孕妇作为对照组,分别采用Sysmex CA-1500全自动血凝分析仪和Beckman AU640全自动生化分析仪检测此两组产前产后的凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)4项指标和D-Dimer、FDP的值并进行比较分析。结果产后出血组凝血功能4项及D-Dimer,FDP检测值异常率产前及产后均高于同期对照组(P0.01);产后出血组PT、APTT、D-Dimer、FDP在产前及产后两个时期均高于同期对照组(P0.01);产后出血组PT、APTT、D-Dimer、FDP产后高于产前(P0.01),但是FIB产后低于产前(P0.05),TT产前、产后差异无统计学意义(P0.05)。结论及时积极对孕产妇进行产前凝血功能4项、FDP、D-Dimer检测有助于提前预防产后大出血的发生及降低孕妇产后出血的病死率,产前和产后血浆FDP、DDimer水平变化对产后出血更具有临床预警价值。
[Abstract]:Objective to investigate the clinical application of fibrinogen degradation product (FDP) D-Dimer (D-Dimer) in the diagnosis of postpartum hemorrhage. Methods 46 pregnant women with postpartum hemorrhage (more than or equal to 500 mL) were selected as postpartum hemorrhage group, and 50 normal pregnant women (less than 500 mL) as control group. The prothrombin time (PT), activated partial prothrombin time (APTT), thrombin time (TT), fibrinogen (FIB) and D-Dimer FDP were measured by Sysmex CA-1500 automatic hemagglutination analyzer and Beckman AU640 automatic biochemical analyzer. And makes a comparative analysis of the value of. Results the abnormal rates of 4 items of coagulation function and D-Dimern FDP in postpartum hemorrhage group were higher than those in control group (P0.01), PTT APTTD-Dimer FDP in postpartum hemorrhage group was higher than that in the same period (P0.01), and that in postpartum hemorrhage group was higher than that in postpartum hemorrhage group (P0.01). Prenatal (P0.01), but FIB postpartum is lower than antenatal (P0.05) TT prenatal, Postpartum difference was not statistically significant (P0.05). Conclusion it is helpful to prevent postpartum haemorrhage and reduce the mortality rate of postpartum hemorrhage by detecting 4 items of blood coagulation function of pregnant women in time and actively. The changes of plasma FDPndimer level in prenatal and postpartum were more valuable for clinical early warning of postpartum hemorrhage.
【作者单位】：四川省自贡市第四人民医院检验科;
【分类号】：R714.461;R446.1

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