妊娠糖尿病患者糖化血红蛋白与新生儿低血糖发病风险的关系

发布时间：2018-06-29 13:57

本文选题：糖尿病 + 妊娠　；参考：《中国全科医学》2015年08期

【摘要】：目的探讨妊娠糖尿病(GDM)患者糖化血红蛋白(Hb A1c)水平与新生儿低血糖(NH)发生的关系。方法连续收集2010年5月—2014年5月在海军安庆医院建卡定期产检、分娩的604例确诊的GDM患者,按产前Hb A1c水平分为G1组(n=375,Hb A1c5.5%),G2组(n=108,Hb A1c5.5%~6.5%),G3组(n=121,Hb A1c6.5%)。对GDM患者分娩的新生儿进行出生后30 min及2、6、12 h时血糖检测。结果 604例GDM患者分娩的新生儿中120例发生NH(19.9%):G1组NH发生率为15.2%(57例),G2组为21.3%(23例),G3组为33.1%(40例)。出生后30 min时G2、G3组正常新生儿血糖水平均低于G1组,2 h时G3组正常新生儿血糖水平低于G1、G2组,12 h时G3组新生儿血糖水平低于G1组(P0.05)。出生后30 min及2、6 h时G2、G3组NH患儿血糖水平低于G1组,12 h时G3组NH患儿血糖水平低于G1组(P0.05);出生后30 min时,3组NH患儿血糖水平均2.2 mmol/L。NH患儿母亲产前Hb A1c水平与NH患儿出生后30 min时血糖水平呈负相关(r=-0.401,P0.05)。结论 GDM患者Hb A1c水平越高,NH的发生率越高、病情程度越严重,Hb A1c6.5%时尤其应该注意。新生儿出生30 min是诊断NH的集中时段,应尽早纠正低血糖。
[Abstract]:Objective to investigate the relationship between HbA1c level and neonatal hypoglycemia (NH) in gestational diabetes mellitus (GDM). Methods 604 confirmed GDM patients were collected from May 2010 to May 2014 in Naval Anqing Hospital. According to the level of HbA1c, they were divided into G 1 group (n = 375) and G _ 2 group (n = 108) and G _ 3 group (n = 121H _ b A _ 1c _ (6.5%). The blood glucose of newborn born with GDM was measured at 30 min and 12 h after birth. Results in 604 cases of GDM, the incidence of NH in 120 neonates (19.9%) was 15.2% (57 cases) in G _ 1 group, 21.3% (23 cases) in G _ 2 group and 33.1% (40 cases) in G _ 3 group. At 30 min after birth, the blood glucose level of normal neonates in G2G3 group was lower than that in G1 group at 2 h after birth (P0.05). The blood glucose level in G3 group was lower than that in G1 group at 12 h after birth (P0.05). At 30 min and 2 h after birth, the blood glucose level of NH group in G2G3 group was lower than that in G1 group at 12 h after birth (P0.05), and the blood glucose level of NH3 group 30 min after birth was 2.2 mmol / L NH. Mothers' HbA1c level and NH1 / NH level were significantly lower than those in G1 group at 30 min and 6 h after birth (P0.05), and at 30 min after birth, the blood glucose level of NH3 group was lower than that of G1 group (P0.05). The blood glucose level was negatively correlated at 30 min after birth (r = -0.401, P 0.05). Conclusion the higher the HbA1c level, the higher the incidence of NH in GDM patients, especially when HB A1c6.5% is more serious. Neonatal 30 min is the centralized time for diagnosis of NH, and hypoglycemia should be corrected as soon as possible.
【作者单位】：中国人民解放军海军安庆医院妇产科;望江县人民医院;
【分类号】：R714.256;R722.1

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